In primary adult rat hepatocytes, des(1‑3)IGF-I did not affect acid-labile subunit release.
In plain wordsIn cells from rats, des(1‑3)IGF-I did not change acid-labile subunit release compared with control.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- No significant changeAcid-labile subunit release
- Study
ratn: not reported in source
Primary adult rat hepatocytes- Comparator
- Vehicle control
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- Dose not stated
Source sentences
2) the release of ALS by adult rat hepatocytes is not affected by the presence during the incubation of des(1-3)IGF-I or IGF-II;
1 context sentence(design, population, supporting numbers)
The regulation of ALS release was evaluated in the conditioned medium of adult rat hepatocytes exposed to increasing concentrations of test substances or to vehicle alone (control), after gel filtration in basic conditions, by immunoblot using an antiserum generated against the N-terminal 34 amino acids of human ALS.