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Study · Measured the body's own peptide · 1996

4 results

Interleukin-1 beta-induced effects on plasma oxytocin and arginine vasopressin: role of adrenal steroids and route of administration.

Harbuz MS, Chover-Gonzalez AJ, Conde GL, Renshaw D, Lightman SL, Jessop DS

Neuroimmunomodulation1 Nov 1996Cited by 8 (Europe PMC)

PMID9266547 (opens in a new tab)DOI10.1159/000097296 (opens in a new tab)PepBankPUB-09266547
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In intact rats, intraperitoneal IL-1 beta did not increase plasma oxytocin.

    In plain wordsIn intact rats, IL-1 beta injected into the belly did not raise the body's own oxytocin in the blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin after intraperitoneal IL-1 beta in intact rats
    Study

    ratn: not reported in source

    intact rats given IL-1 beta intraperitoneally
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    We were unable to demonstrate an increase in plasma oxytocin in intact rats in response to intraperitoneal injection of IL-1 beta.
    1 context sentence
    Summary · context
    In the present study, we have investigated the effect of intraperitoneal injection of recombinant human interleukin (IL)-1 beta on oxytocin release in sham-operated controls, adrenalectomized (ADX) rats and ADX rats given either low or high doses of the synthesis glucocorticoid dexamethasone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adrenalectomized rats, intraperitoneal IL-1 beta caused a substantial and sustained increase in plasma oxytocin.

    In plain wordsIn rats with the adrenal glands removed, IL-1 beta raised the body's own oxytocin in the blood for a long time.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after intraperitoneal IL-1 beta in adrenalectomized rats
    Study

    ratn: not reported in source

    adrenalectomized rats given IL-1 beta intraperitoneally
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In contrast, we found a substantial and sustained increase in plasma oxytocin concentrations in ADX rats.
    1 context sentence
    Summary · context
    In the present study, we have investigated the effect of intraperitoneal injection of recombinant human interleukin (IL)-1 beta on oxytocin release in sham-operated controls, adrenalectomized (ADX) rats and ADX rats given either low or high doses of the synthesis glucocorticoid dexamethasone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adrenalectomized rats, low and high doses of dexamethasone abolished the IL-1 beta-induced rise in plasma oxytocin.

    In plain wordsIn rats with the adrenal glands removed, dexamethasone stopped the IL-1 beta rise in the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseDexamethasone effect on IL-1 beta-induced plasma oxytocin rise in adrenalectomized rats
    Study

    ratn: not reported in source

    adrenalectomized rats given dexamethasone and IL-1 beta
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    This stimulation was abolished by treatment with dexamethasone at both the low and high doses.
    1 context sentence
    Summary · context
    In the present study, we have investigated the effect of intraperitoneal injection of recombinant human interleukin (IL)-1 beta on oxytocin release in sham-operated controls, adrenalectomized (ADX) rats and ADX rats given either low or high doses of the synthesis glucocorticoid dexamethasone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, central injection of IL-1 beta did not increase plasma oxytocin, although it raised circulating corticosterone.

    In plain wordsIn rats, IL-1 beta injected into the brain did not raise the body's own oxytocin in the blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin after central IL-1 beta injection
    Study

    ratn: not reported in source

    sham-operated and adrenalectomized rats given IL-1 beta centrally
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Following central injection of IL-1 beta, we were unable to demonstrate any increase in either oxytocin or AVP, despite the ability of this dose of cytokine to stimulate the hypothalamo-pituitary-adrenal axis, as evidenced by increased circulating corticosterone.
    1 context sentence
    Summary · context
    In the present study, we have investigated the effect of intraperitoneal injection of recombinant human interleukin (IL)-1 beta on oxytocin release in sham-operated controls, adrenalectomized (ADX) rats and ADX rats given either low or high doses of the synthesis glucocorticoid dexamethasone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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