Amelioration of type II collagen induced arthritis in rats by treatment with thymulin.

Aono H, Morishita M, Sasano M, Okamoto M, Okahara A, Nakata K, Mita S

The Journal of rheumatology1 Aug 1997Cited by 2 (Europe PMC)

PMID9263152PepBankPUB-09263152

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with collagen-induced arthritis, thymulin reduced hind paw swelling compared with control rats.
In plain wordsIn rats with arthritis, thymulin reduced paw swelling compared with control rats.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseHind paw swelling
Study
ratn: not reported in source
Collagen-induced arthritis in SD rats
Comparator
Control rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Thymulin diminished hind paw swelling and onset of arthritis compared with control rats.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate the effects of thymulin (serum thymic factor + Zn2+) in collagen induced arthritis (CIA) in rats.
Summary · context
SD rats were immunized with bovine type II collagen plus Freund's incomplete adjuvant, and thymulin was administered intraperitoneally on the first day of first immunization.
Report a problemFND-0926315202
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, thymulin diminished the onset of collagen-induced arthritis compared with control rats.
In plain wordsIn rats, thymulin reduced arthritis onset compared with control rats.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseArthritis onset
Study
ratn: not reported in source
Collagen-induced arthritis in SD rats
Comparator
Control rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Thymulin diminished hind paw swelling and onset of arthritis compared with control rats.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate the effects of thymulin (serum thymic factor + Zn2+) in collagen induced arthritis (CIA) in rats.
Summary · context
SD rats were immunized with bovine type II collagen plus Freund's incomplete adjuvant, and thymulin was administered intraperitoneally on the first day of first immunization.
Report a problemFND-0926315203
03AnimalAnimal study (in vivo)Mechanism
In rats with collagen-induced arthritis, thymulin reduced serum anti-type II collagen antibody levels.
In plain wordsIn rats with arthritis, thymulin reduced collagen antibody levels compared with control rats.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseSerum anti-type II collagen antibody
Study
ratn: not reported in source
Collagen-induced arthritis in SD rats
Comparator
Control rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
The serum anti-type II collagen antibody level was also reduced by thymulin.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate the effects of thymulin (serum thymic factor + Zn2+) in collagen induced arthritis (CIA) in rats.
Summary · context
SD rats were immunized with bovine type II collagen plus Freund's incomplete adjuvant, and thymulin was administered intraperitoneally on the first day of first immunization.
Report a problemFND-0926315204
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with collagen-induced arthritis, thymulin inhibited granulation tissue formation in affected joints.
In plain wordsIn rats with arthritis, thymulin reduced granulation tissue formation compared with control rats.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseJoint granulation tissue formation
Study
ratn: not reported in source
Collagen-induced arthritis in SD rats
Comparator
Control rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Histopathological examination showed inhibition of granulation tissue and new bone formation after injection of thymulin.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate the effects of thymulin (serum thymic factor + Zn2+) in collagen induced arthritis (CIA) in rats.
Summary · context
SD rats were immunized with bovine type II collagen plus Freund's incomplete adjuvant, and thymulin was administered intraperitoneally on the first day of first immunization.
Report a problemFND-0926315205
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with collagen-induced arthritis, thymulin inhibited new bone formation in affected joints.
In plain wordsIn rats with arthritis, thymulin reduced new bone formation compared with control rats.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseJoint new bone formation
Study
ratn: not reported in source
Collagen-induced arthritis in SD rats
Comparator
Control rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Histopathological examination showed inhibition of granulation tissue and new bone formation after injection of thymulin.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate the effects of thymulin (serum thymic factor + Zn2+) in collagen induced arthritis (CIA) in rats.
Summary · context
SD rats were immunized with bovine type II collagen plus Freund's incomplete adjuvant, and thymulin was administered intraperitoneally on the first day of first immunization.
Report a problemFND-0926315206

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

06AnimalEndogenous levelAnimal study (in vivo)Other
In rats with collagen-induced arthritis, natural serum thymulin levels were lower than in untreated rats.
In plain wordsIn rats with arthritis, natural thymulin levels were lower than in untreated rats.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseSerum thymulin levels
Study
ratn: not reported in source
Collagen-induced arthritis in SD rats
Comparator
Untreated rats
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Serum thymulin levels in CIA rats were significantly lower than in untreated rats.
2 context sentences(design, population, supporting numbers)
Summary · context
To investigate the effects of thymulin (serum thymic factor + Zn2+) in collagen induced arthritis (CIA) in rats.
Summary · context
SD rats were immunized with bovine type II collagen plus Freund's incomplete adjuvant, and thymulin was administered intraperitoneally on the first day of first immunization.
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0926315201

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:55 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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