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Study · Animal study (in vivo) · rat · 1997

4 results

Insulin-like growth factor-I ameliorates delayed kidney graft function and the acute nephrotoxic effects of cyclosporine.

Maestri M, Dafoe DC, Adams GA, Gaspari A, Luzzana F, Innocente F, Rademacher J, Dionigi P, Barbieri A, Zonta F, Zonta A, Rabkin R

Transplantation1 Jul 1997Cited by 9 (Europe PMC)

PMID9256171 (opens in a new tab)DOI10.1097/00007890-199707270-00001 (opens in a new tab)PepBankPUB-09256171
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In Lewis rats, des(1‑3)IGF-I did not accelerate skin allograft rejection.

    In plain wordsIn rats, des(1‑3)IGF-I did not accelerate skin graft rejection.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeSkin graft rejection
    Study

    ratn: not reported in source

    Lewis rats with skin allografts
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    P value
    0.57 NA
    skin graft rejection

    Source sentences

    Summary
    Des(1-3)IGF-I did not accelerate the rejection of the skin grafts (P=0.57).
    1 context sentence
    Summary · context
    First, because of the immunogenic properties of IGF-I, we assessed the effect of des(1-3)IGF-I on the rejection of skin allografts in Lewis rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a syngenic renal transplant model, des(1‑3)IGF-I improved early graft function.

    In plain wordsIn animals with kidney transplants, des(1‑3)IGF-I improved early graft function.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseEarly graft function
    Study

    n: not reported in source

    Syngenic renal transplant model of delayed graft function
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The administration of this peptide in a model of syngenic renal transplant improved the early function of the graft.
    1 context sentence
    Summary · context
    Next we determined whether treatment with des(1-3)IGF-I influences the early function of transplanted kidneys in a model of DGF induced by a combination of warm and cold ischemia.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In transplanted animals, des(1‑3)IGF-I treatment produced significantly better postoperative creatinine values.

    In plain wordsIn animals with kidney transplants, postoperative creatinine values were significantly better with des(1‑3)IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Direction not reportedPostoperative creatinine
    Study

    n: not reported in source

    Syngenic renal transplant model of delayed graft function
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Postoperative values of creatinine and blood urea nitrogen were significantly better (P<0.05) in treated animals.
    1 context sentence
    Summary · context
    The administration of this peptide in a model of syngenic renal transplant improved the early function of the graft.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In transplanted animals, des(1‑3)IGF-I treatment produced significantly better postoperative blood urea nitrogen values.

    In plain wordsIn animals with kidney transplants, postoperative blood urea nitrogen values were significantly better with des(1‑3)IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Direction not reportedPostoperative blood urea nitrogen
    Study

    n: not reported in source

    Syngenic renal transplant model of delayed graft function
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Postoperative values of creatinine and blood urea nitrogen were significantly better (P<0.05) in treated animals.
    1 context sentence
    Summary · context
    The administration of this peptide in a model of syngenic renal transplant improved the early function of the graft.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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