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Study · Animal study (in vivo) · rat and rhesus monkeys · 1997

4 results

The stabilization and encapsulation of human growth hormone into biodegradable microspheres.

Johnson OL, Jaworowicz W, Cleland JL, Bailey L, Charnis M, Duenas E, Wu C, Shepard D, Magil S, Last T, Jones AJ, Putney SD

Pharmaceutical research1 Jun 1997Cited by 140 (Europe PMC)

PMID9210189 (opens in a new tab)DOI10.1023/a:1012142204132 (opens in a new tab)PepBankPUB-09210189
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats and juvenile rhesus monkeys, the serum rhGH profile was reproducible after three sequential monthly microsphere doses.

    In plain wordsIn rats and juvenile rhesus monkeys, blood rhGH profiles were reproducible after three sequential monthly microsphere doses.

    Peptide
    HGH (somatotropin)
    Outcome
    Direction not reportedRepeated-dose serum rhGH profile reproducibility
    Study

    rats and rhesus monkeysn: not reported in source

    rats and juvenile rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rats and rhesus monkeys).

    Source sentences

    Summary
    The serum rhGH profile, after three sequential monthly doses of the one formulation examined, was reproducible and showed no dose accumulation.
    1 context sentence
    Summary · context
    In addition, the in vivo release profile was determined after subcutaneous administration of the microspheres to rats and juvenile rhesus monkeys.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats and juvenile rhesus monkeys, three sequential monthly rhGH microsphere doses showed no dose accumulation.

    In plain wordsIn rats and juvenile rhesus monkeys, rhGH did not accumulate after three sequential monthly microsphere doses.

    Peptide
    HGH (somatotropin)
    Outcome
    Direction not reportedDose accumulation
    Study

    rats and rhesus monkeysn: not reported in source

    rats and juvenile rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rats and rhesus monkeys).

    Source sentences

    Summary
    The serum rhGH profile, after three sequential monthly doses of the one formulation examined, was reproducible and showed no dose accumulation.
    1 context sentence
    Summary · context
    In addition, the in vivo release profile was determined after subcutaneous administration of the microspheres to rats and juvenile rhesus monkeys.

Studies that did not test the peptide alone2

In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking HGH (somatotropin).

  1. 03AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics

    In rats or monkeys, rhGH microspheres elevated serum rhGH for up to one month, more than 20-fold longer than the same amount in solution.

    In plain wordsIn rats or monkeys, rhGH microspheres maintained elevated blood rhGH more than 20-fold longer than the same amount injected as solution.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseDuration of serum rhGH elevation
    Study

    rats and rhesus monkeysn: not reported in source

    rats and juvenile rhesus monkeys
    Comparator
    Same amount of rhGH injected subcutaneously as solution
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    In vivo, microsphere administration to rats or monkeys induced elevated levels of serum rhGH for up to one month, more than 20-fold longer than was induced by the same amount of protein injected subcutaneously as a solution.
    1 context sentence
    Summary · context
    In addition, the in vivo release profile was determined after subcutaneous administration of the microspheres to rats and juvenile rhesus monkeys.

    In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).

  2. 04AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics

    In rats and juvenile rhesus monkeys, rhGH release rates differed among three microsphere formulations according to PLGA molecular weight and hydrophobicity.

    In plain wordsIn rats and juvenile rhesus monkeys, rhGH release rates differed between microsphere formulations according to polymer properties.

    Peptide
    HGH (somatotropin)
    Outcome
    MixedFormulation-dependent protein release rate
    Study

    rats and rhesus monkeysn: not reported in source

    rats and juvenile rhesus monkeys
    Comparator
    Other microsphere formulations
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The rate of protein release differed between the three microsphere formulations and was determined by the molecular weight and hydrophobicity of the PLGA.
    1 context sentence
    Summary · context
    In addition, the in vivo release profile was determined after subcutaneous administration of the microspheres to rats and juvenile rhesus monkeys.

    In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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