A double-blind randomized study of the treatment of endometriosis with nafarelin or nafarelin plus norethisterone.

Bergqvist A, Jacobson J, Harris S

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology1 Jun 1997Cited by 12 (Europe PMC)

PMID9209899DOI10.3109/09513599709152533PepBankPUB-09209899

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialSafety outcome
In women with endometriosis, hot flush frequency after the first month did not differ between nafarelin 200 and 400 micrograms daily.
In plain wordsHot flush frequency after the first month did not differ between the two nafarelin doses.
Peptide
Nafarelin
Outcome
No significant changeHot flush frequency after first treatment month
Study
n: not reported in source
Comparator
Nafarelin 400 micrograms daily
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 micrograms daily · 6 monthsAs given in this study (human).
Source sentences
Summary
The frequency of hot flushes during the first month of treatment was lowest in Group C, but during the rest of treatment there were no differences between the groups.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized, double-blind parallel group study was performed in two centers and 49 women with endometriosis diagnosed laparoscopically were included.
Summary · context
The objective of this study was to compare the efficacy of nafarelin 200 micrograms (Group A), nafarelin 400 micrograms (Group B) and the combination of nafarelin 200 micrograms and norethisterone 1.2 mg (Group C) daily,
Report a problemFND-0920989905
02HumanNon-randomized trialEfficacy outcome
In women with endometriosis, pelvic examination scores decreased significantly from baseline with nafarelin 200 micrograms daily at 3 and 6 months.
In plain wordsPelvic examination scores decreased from baseline with nafarelin 200 micrograms daily at 3 and 6 months.
Peptide
Nafarelin
Outcome
DecreasePelvic examination total score at 3 and 6 months
Study
n: not reported in source
Comparator
Baseline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 micrograms daily · 6 monthsAs given in this study (human).
Source sentences
Summary
At 3 and 6 months the pelvic examination total score had decreased significantly in all three groups.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized, double-blind parallel group study was performed in two centers and 49 women with endometriosis diagnosed laparoscopically were included.
Summary · context
The objective of this study was to compare the efficacy of nafarelin 200 micrograms (Group A), nafarelin 400 micrograms (Group B) and the combination of nafarelin 200 micrograms and norethisterone 1.2 mg (Group C) daily,
Report a problemFND-0920989901
03HumanNon-randomized trialEfficacy outcome
In women with endometriosis, pelvic examination scores decreased significantly from baseline with nafarelin 400 micrograms daily at 3 and 6 months.
In plain wordsPelvic examination scores decreased from baseline with nafarelin 400 micrograms daily at 3 and 6 months.
Peptide
Nafarelin
Outcome
DecreasePelvic examination total score at 3 and 6 months
Study
n: not reported in source
Comparator
Baseline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
400 micrograms daily · 6 monthsAs given in this study (human).
Source sentences
Summary
At 3 and 6 months the pelvic examination total score had decreased significantly in all three groups.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized, double-blind parallel group study was performed in two centers and 49 women with endometriosis diagnosed laparoscopically were included.
Summary · context
The objective of this study was to compare the efficacy of nafarelin 200 micrograms (Group A), nafarelin 400 micrograms (Group B) and the combination of nafarelin 200 micrograms and norethisterone 1.2 mg (Group C) daily,
Report a problemFND-0920989902
04HumanNon-randomized trialEfficacy outcome
In women with endometriosis, nafarelin 400 micrograms daily significantly reduced total endometriosis scores from baseline.
In plain wordsTotal endometriosis scores decreased from baseline with nafarelin 400 micrograms daily.
Peptide
Nafarelin
Outcome
DecreaseTotal endometriosis score
Study
n: not reported in source
Comparator
Baseline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
400 micrograms daily · 6 monthsAs given in this study (human).
Source sentences
Summary
The total endometriosis score was significantly reduced in Groups B and C.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized, double-blind parallel group study was performed in two centers and 49 women with endometriosis diagnosed laparoscopically were included.
Summary · context
The objective of this study was to compare the efficacy of nafarelin 200 micrograms (Group A), nafarelin 400 micrograms (Group B) and the combination of nafarelin 200 micrograms and norethisterone 1.2 mg (Group C) daily,
Report a problemFND-0920989903
05HumanNon-randomized trialEfficacy outcome
In women with endometriosis, total symptom scores decreased significantly from baseline after 2 months with nafarelin 400 micrograms daily.
In plain wordsSymptom scores decreased from baseline after 2 months with nafarelin 400 micrograms daily.
Peptide
Nafarelin
Outcome
DecreaseTotal symptom score after 2 months
Study
n: not reported in source
Comparator
Baseline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
400 micrograms dailyAs given in this study (human).
Source sentences
Summary
After 2 months the total symptom score showed a significant decrease in Groups B and C.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized, double-blind parallel group study was performed in two centers and 49 women with endometriosis diagnosed laparoscopically were included.
Summary · context
The objective of this study was to compare the efficacy of nafarelin 200 micrograms (Group A), nafarelin 400 micrograms (Group B) and the combination of nafarelin 200 micrograms and norethisterone 1.2 mg (Group C) daily,
Report a problemFND-0920989904

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

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