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Study · Animal study (in vivo) · mouse · 1997

7 results

Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism.

Sun BF, Kobayashi H, Le N, Yoo TM, Drumm D, Paik CH, McAfee JG, Carrasquillo JA

Cancer research1 Jul 1997Cited by 10 (Europe PMC)

PMID9205087 (opens in a new tab)PepBankPUB-09205087
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In nude mice, radiolabeled des(1‑3)IGF-I bound serum proteins mainly in a complex of molecular weight 150,000.

    In plain wordsIn mice, labeled des(1‑3)IGF-I mainly bound blood proteins in a large complex.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Not applicableSerum-binding protein complex
    Study

    mousen: not reported in source

    Tumor-bearing nude mice
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    125I-labeled des(1-3)IGF-I was bound to serum-binding proteins, mainly in a complex with a molecular weight of M(r) 150,000.
    1 context sentence
    Summary · context
    Additional studies included its catabolism by tumor cells in vitro and its binding to serum IGFBPs in vivo in nude mice.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In tumor-bearing nude mice, normal-tissue radioactivity after radiolabeled des(1‑3)IGF-I decreased quickly, particularly in kidneys.

    In plain wordsIn mice, tissue radioactivity after labeled des(1‑3)IGF-I decreased quickly over time, especially in the kidneys.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseNormal tissue radioactivity over time
    Study

    mousen: not reported in source

    Tumor-bearing nude mice
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The uptake of radioactivity in normal tissues decreased quickly with time, particularly in the kidneys.
    1 context sentence
    Summary · context
    In the present study, we investigated the biodistribution of 125I-labeled des(1-3)IGF-I, a truncated analogue of IGF-I, in tumor-bearing nude mice.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In nude mice, higher des(1‑3)IGF-I doses lowered radioactivity in normal tissues except the stomach and spleen versus no carrier addition.

    In plain wordsIn mice, higher des(1‑3)IGF-I doses lowered tissue radioactivity versus no added carrier, except in the stomach and spleen.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseNormal tissue radioactivity with higher carrier dose
    Study

    mousen: not reported in source

    Tumor-bearing nude mice
    Comparator
    No carrier-added des(1-3)IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In mice receiving higher doses of des(1-3)IGF-I, the radioactivity in all normal tissues was lower than in the mice with no carrier-added des(1-3)IGF-I, except in the stomach and spleen.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In tumor-bearing nude mice, lower specific activity of radiolabeled des(1‑3)IGF-I accelerated blood clearance.

    In plain wordsIn mice, labeled des(1‑3)IGF-I cleared from blood faster at lower specific activity than at higher specific activity.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseBlood clearance with lower specific activity
    Study

    mousen: not reported in source

    Tumor-bearing nude mice
    Comparator
    Higher specific activity
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Lower specific activity of 125I-labeled des(1-3)IGF-I resulted in altered biodistribution, including faster blood clearance and higher tumor uptake, by decreasing the formation of complexes with IGFBPs.
    1 context sentence
    Summary · context
    In the present study, we investigated the biodistribution of 125I-labeled des(1-3)IGF-I, a truncated analogue of IGF-I, in tumor-bearing nude mice.
  5. 05AnimalAnimal study (in vivo)Pharmacokinetics

    In tumor-bearing nude mice, lower specific activity of radiolabeled des(1‑3)IGF-I increased tumor uptake.

    In plain wordsIn mice, labeled des(1‑3)IGF-I entered tumors more at lower specific activity than at higher specific activity.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseTumor uptake with lower specific activity
    Study

    mousen: not reported in source

    Tumor-bearing nude mice
    Comparator
    Higher specific activity
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Lower specific activity of 125I-labeled des(1-3)IGF-I resulted in altered biodistribution, including faster blood clearance and higher tumor uptake, by decreasing the formation of complexes with IGFBPs.
    1 context sentence
    Summary · context
    In the present study, we investigated the biodistribution of 125I-labeled des(1-3)IGF-I, a truncated analogue of IGF-I, in tumor-bearing nude mice.
  6. 06AnimalAnimal study (in vivo)Pharmacokinetics

    In tumor-bearing nude mice, lower specific activity of radiolabeled des(1‑3)IGF-I decreased IGFBP complex formation.

    In plain wordsIn mice, labeled des(1‑3)IGF-I formed fewer IGFBP complexes at lower specific activity than at higher specific activity.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseIGFBP complex formation with lower specific activity
    Study

    mousen: not reported in source

    Tumor-bearing nude mice
    Comparator
    Higher specific activity
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Lower specific activity of 125I-labeled des(1-3)IGF-I resulted in altered biodistribution, including faster blood clearance and higher tumor uptake, by decreasing the formation of complexes with IGFBPs.
    1 context sentence
    Summary · context
    In the present study, we investigated the biodistribution of 125I-labeled des(1-3)IGF-I, a truncated analogue of IGF-I, in tumor-bearing nude mice.
  7. 07LabIn vitro (cells)Pharmacokinetics

    In tumor cells in vitro, radiolabeled des(1‑3)IGF-I catabolized rapidly at 37 degrees C but not at 4 degrees C.

    In plain wordsIn lab tests, labeled des(1‑3)IGF-I broke apart rapidly at 37 degrees C but not at 4 degrees C.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseTemperature-dependent catabolism
    Study

    n: not reported in source

    Tumor cells in vitro
    Comparator
    4 degrees C incubation
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our data showed that 125I-labeled des(1-3)IGF-I catabolized very fast, with a rapid appearance of nonprecipitable iodine, when incubated at 37 degrees C, but it was not catabolized at 4 degrees C incubation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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