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Study · In vitro (cells) · helix pomatia · 1997

5 results

The effects of piracetam and its novel peptide analogue GVS-111 on neuronal voltage-gated calcium and potassium channels.

Solntseva EI, Bukanova JV, Ostrovskaya RU, Gudasheva TA, Voronina TA, Skrebitsky VG

General pharmacology1 Jul 1997Cited by 12 (Europe PMC)

PMID9195198 (opens in a new tab)DOI10.1016/s0306-3623(96)00529-0 (opens in a new tab)PepBankPUB-09195198
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In isolated snail neurons, calcium current resisted GVS-111 in more than half of tested cells.

    In plain wordsIn lab tests with snail neurons, calcium current resisted GVS-111 in more than half of cells.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeCalcium current in resistant cells
    Study

    Helix pomatian: not reported in source

    Isolated snail neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · bath applicationAs given in this study (Helix pomatia).

    Source sentences

    Summary
    In more than half of the tested cells, ICa was resistant to both piracetam and GVS-111.
    2 context sentences
    Summary · context
    With the use of the two-microelectrode voltage-clamp method, three types of voltage-activated ionic currents were examined in isolated neurons of the snail Helix pomatia: high-threshold Ca2+ current (ICa), high-threshold Ca(2+)-dependent K+ current (IK(Ca)) and high-threshold K+ current independent of Ca2+ (IK(V)).
    Summary · context
    The effect of bath application of the nootropics piracetam and a novel piracetam peptide analog, ethyl ester of N-phenyl-acetyl-L-prolyl-glycine (GVS-111), on these three types of voltage-activated ionic currents was studied.
  2. 02LabIn vitro (cells)Mechanism

    In the remaining isolated snail neurons, GVS-111 decreased calcium current by 39 +/- 14%.

    In plain wordsIn lab tests with responsive snail neurons, GVS-111 decreased calcium current.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseCalcium current in responsive cells
    Study

    Helix pomatian: not reported in source

    Isolated snail neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2 microM · bath applicationAs given in this study (Helix pomatia).

    Measurements

    Calcium current decrease
    39%
    responsive cells; +/- 14%

    Source sentences

    Summary
    In the rest of the cells, ICa decreased 19 +/- 7% with 2 mM of piracetam and 39 +/- 14% with 2 microM of GVS-111.
    2 context sentences
    Summary · context
    With the use of the two-microelectrode voltage-clamp method, three types of voltage-activated ionic currents were examined in isolated neurons of the snail Helix pomatia: high-threshold Ca2+ current (ICa), high-threshold Ca(2+)-dependent K+ current (IK(Ca)) and high-threshold K+ current independent of Ca2+ (IK(V)).
    Summary · context
    The effect of bath application of the nootropics piracetam and a novel piracetam peptide analog, ethyl ester of N-phenyl-acetyl-L-prolyl-glycine (GVS-111), on these three types of voltage-activated ionic currents was studied.
  3. 03LabIn vitro (cells)Mechanism

    In isolated snail neurons, GVS-111 suppressed calcium-independent potassium current by 49 +/- 18% in two-thirds of cells.

    In plain wordsIn lab tests with snail neurons, GVS-111 suppressed calcium-independent potassium current in two-thirds of cells.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseCalcium-independent potassium current
    Study

    Helix pomatian: not reported in source

    Isolated snail neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 microM · bath applicationAs given in this study (Helix pomatia).

    Measurements

    Potassium current suppression
    49%
    two-thirds of cells; +/- 18%

    Source sentences

    Summary
    However, IK(V) in two-thirds of the cells was sensitive to GVS-111, being suppressed 49 +/- 18% with 1 microM GVS-111.
    2 context sentences
    Summary · context
    With the use of the two-microelectrode voltage-clamp method, three types of voltage-activated ionic currents were examined in isolated neurons of the snail Helix pomatia: high-threshold Ca2+ current (ICa), high-threshold Ca(2+)-dependent K+ current (IK(Ca)) and high-threshold K+ current independent of Ca2+ (IK(V)).
    Summary · context
    The effect of bath application of the nootropics piracetam and a novel piracetam peptide analog, ethyl ester of N-phenyl-acetyl-L-prolyl-glycine (GVS-111), on these three types of voltage-activated ionic currents was studied.
  4. 04LabIn vitro (cells)Mechanism

    In isolated snail neurons, calcium-dependent potassium current was the most sensitive tested current to GVS-111 and piracetam.

    In plain wordsIn lab tests with snail neurons, calcium-dependent potassium current was the most sensitive tested current to GVS-111 and piracetam.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicableCalcium-dependent potassium current sensitivity
    Study

    Helix pomatian: not reported in source

    Isolated snail neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · bath applicationAs given in this study (Helix pomatia).

    Source sentences

    Summary
    IK(Ca) appeared to be the most sensitive current of those studied to both piracetam and GVS-111.
    2 context sentences
    Summary · context
    With the use of the two-microelectrode voltage-clamp method, three types of voltage-activated ionic currents were examined in isolated neurons of the snail Helix pomatia: high-threshold Ca2+ current (ICa), high-threshold Ca(2+)-dependent K+ current (IK(Ca)) and high-threshold K+ current independent of Ca2+ (IK(V)).
    Summary · context
    The effect of bath application of the nootropics piracetam and a novel piracetam peptide analog, ethyl ester of N-phenyl-acetyl-L-prolyl-glycine (GVS-111), on these three types of voltage-activated ionic currents was studied.
  5. 05LabIn vitro (cells)Mechanism

    In most isolated snail neurons, GVS-111 decreased calcium-dependent potassium current amplitude by 69 +/- 24%.

    In plain wordsIn lab tests with snail neurons, GVS-111 decreased calcium-dependent potassium current amplitude in most cells.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseCalcium-dependent potassium current amplitude
    Study

    Helix pomatian: not reported in source

    Isolated snail neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.1 microM · bath applicationAs given in this study (Helix pomatia).

    Measurements

    Potassium current amplitude decrease
    69%
    most cells; +/- 24%

    Source sentences

    Summary
    Piracetam at 1 mM and GVS-111 at 0.1 microM decreased the amplitude of IK(Ca) in most of the cells examined by 49 +/- 19% and 69 +/- 24%, respectively.
    2 context sentences
    Summary · context
    With the use of the two-microelectrode voltage-clamp method, three types of voltage-activated ionic currents were examined in isolated neurons of the snail Helix pomatia: high-threshold Ca2+ current (ICa), high-threshold Ca(2+)-dependent K+ current (IK(Ca)) and high-threshold K+ current independent of Ca2+ (IK(V)).
    Summary · context
    The effect of bath application of the nootropics piracetam and a novel piracetam peptide analog, ethyl ester of N-phenyl-acetyl-L-prolyl-glycine (GVS-111), on these three types of voltage-activated ionic currents was studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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