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Study · Animal study (in vivo) · rat · 1997

4 results

Simultaneous determination of glycyl-L-histidyl-L-lysine and its metabolite, L-histidyl-L-lysine, in rat plasma by high-performance liquid chromatography with post-column derivatization.

Endo T, Miyagi M, Ujiie A

Journal of chromatography. B, Biomedical sciences and applications1 Apr 1997Cited by 7 (Europe PMC)

PMID9187381 (opens in a new tab)DOI10.1016/s0378-4347(96)00460-4 (opens in a new tab)PepBankPUB-09187381
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats after a single intravenous dose, GHK rapidly degraded to HK.

    In plain wordsIn rats, GHK rapidly degraded to HK after a single intravenous dose.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    Not applicableGHK degradation
    Study

    ratsn: not reported in source

    intravenous GHK pharmacokinetics
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenouslyAs given in this study (rats).

    Source sentences

    Summary
    GHK was rapidly degraded to HK, which was eliminated rapidly.
    1 context sentence
    Summary · context
    The developed method was applied to the pharmacokinetic study of GHK after a single dose was administered intravenously to rats.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats after intravenous GHK, its metabolite HK was rapidly eliminated.

    In plain wordsIn rats, HK was rapidly eliminated after an intravenous GHK dose.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    Not applicableGHK metabolite elimination
    Study

    ratsn: not reported in source

    intravenous GHK pharmacokinetics
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenouslyAs given in this study (rats).

    Source sentences

    Summary
    GHK was rapidly degraded to HK, which was eliminated rapidly.
    1 context sentence
    Summary · context
    The developed method was applied to the pharmacokinetic study of GHK after a single dose was administered intravenously to rats.

Studies that did not test the peptide alone2

In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  1. 03LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Activity measurement

    In rat plasma HPLC analysis, the GHK detection limit was 50 ng/ml.

    In plain wordsIn lab tests of rat plasma, the GHK detection limit was 50 ng/ml.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    Not applicableGHK detection limit
    Study

    ratn: not reported in source

    rat plasma HPLC assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Detection limit
    50 ng/ml
    GHK

    Source sentences

    Summary
    The limit of detection for GHK and HK were 50 and 15 ng/ml, respectively, and the calibration curves were linear in the range 0.1-5.0 microg/ml.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  2. 04LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Activity measurement

    In rat plasma HPLC analysis, the GHK calibration curve was linear from 0.1-5.0 microg/ml.

    In plain wordsIn lab tests of rat plasma, the GHK calibration curve was linear from 0.1-5.0 microg/ml.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    Not applicableGHK calibration linearity
    Study

    ratn: not reported in source

    rat plasma HPLC assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Linear calibration range
    0.1 to 5 microg/ml
    GHK

    Source sentences

    Summary
    The limit of detection for GHK and HK were 50 and 15 ng/ml, respectively, and the calibration curves were linear in the range 0.1-5.0 microg/ml.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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