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Study · In vitro (cells) · 1997

2 results

Proteolysis of insulin-like growth factor-binding protein-3 by human skin keratinocytes in culture in comparison to that in skin interstitial fluid: the role and regulation of components of the plasmin system.

Xu S, Savage P, Burton JL, Sansom J, Holly JM

The Journal of clinical endocrinology and metabolism1 Jun 1997Cited by 9 (Europe PMC)

PMID9177397 (opens in a new tab)DOI10.1210/jcem.82.6.4025 (opens in a new tab)PepBankPUB-09177397
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In HaCaT keratinocytes, preincubation with IGF-I or long R3 IGF-I divergently changed plasminogen activator inhibitor-1 and -2 secretion.

    In plain wordsIn human skin cells in a dish, long R3 IGF-I and IGF-I changed PAI-1 and PAI-2 release in different ways.

    Peptide
    IGF-1 LR3
    Outcome
    MixedPAI-1 and PAI-2 secretion
    Study

    humann: not reported in source

    HaCaT keratinocyte cell line
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preincubation of cells with IGF-I or long R3 IGF-I divergently changed plasminogen activator inhibitor-1 and -2 secretion
    1 context sentence
    Summary · context
    We have investigated this in a human skin keratinocyte cell line HaCaT.
  2. 02LabIn vitro (cells)Mechanism

    In HaCaT keratinocytes, long R3 IGF-I did not block IGFBP-3 proteolysis, whereas IGF-I did.

    In plain wordsIn human skin cells in a dish, long R3 IGF-I did not stop IGFBP-3 breakdown, unlike IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeIGFBP-3 proteolysis
    Study

    humann: not reported in source

    HaCaT keratinocyte cell line
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preincubation of cells with IGF-I or long R3 IGF-I divergently changed plasminogen activator inhibitor-1 and -2 secretion, but only IGF-I blocked IGFBP-3 proteolysis.
    1 context sentence
    Summary · context
    We have investigated this in a human skin keratinocyte cell line HaCaT.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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