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Study · In vitro (cells) · 1997

1 result

Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.

Haskell-Luevano C, Nikiforovich G, Sharma SD, Yang YK, Dickinson C, Hruby VJ, Gantz I

Journal of medicinal chemistry1 May 1997Cited by 51 (Europe PMC)

PMID9171884 (opens in a new tab)DOI10.1021/jm960845e (opens in a new tab)PepBankPUB-09171884
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    At human MC3 and MC5 receptors, the cyclic analogue MTII had lower binding affinity than linear NDP-MSH.

    In plain wordsIn cells, MTII bound two human melanocortin receptors less strongly than NDP-MSH did.

    Peptide
    Melanotan II
    Outcome
    DecreaseBinding affinity at hMC3R and hMC5R versus NDP-MSH
    Study

    humann: not reported in source

    Human melanocortin receptors hMC1R, hMC3R, hMC4R and hMC5R
    Comparator
    NDP-MSH
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, the linear NDP-MSH possessed greater binding affinity for the hMC3R and hMC5R than did the cyclic analogue MTII.
    1 context sentence
    Summary · context
    MTII (Ac-Nle4-c[Asp5,D-Phe7,Lys10]-alpha-MSH(4-10)-NH2) were also examined at each of these melanocortin receptors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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