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Study · Animal study (in vivo) · mouse · 1997

6 results

Effects of thymosin alpha1 on the development of amoeboid microglial cells in the corpus callosum of neonatal BALB/c and athymic mice.

Htain WW, Leong SK, Yuen R, Ling EA

Brain research1 Apr 1997Cited by 5 (Europe PMC)

PMID9163541 (opens in a new tab)DOI10.1016/s0006-8993(97)00108-x (opens in a new tab)PepBankPUB-09163541
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In newborn athymic mice, thymosin alpha1 injections reduced the number of supraventricular amoeboid microglial cells by 27% compared with vehicle.

    In plain wordsIn newborn athymic mice, thymosin alpha1 injections lowered the number of microglial cells in the brain by 27% compared with vehicle.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseAmoeboid microglial cell number, athymic mice
    Study

    mousen: not reported in source

    Newborn athymic and BALB/c mice
    Comparator
    Vehicle injection
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Reduction in microglial cell number
    27%
    athymic mice

    Source sentences

    Summary
    The microglial cells labelled by the lectin GSA I-B4 and the antibody Mac-1 showed a 27% reduction in number in the athymic mice receiving thymosin alpha1 injections compared with those receiving vehicle injections, and
    1 context sentence
    Summary · context
    The present study investigated the effects of intraperitoneal injections of thymosin alpha1 on the supraventricular amoeboid microglial cells (SAMC) in the newborn athymic and normal BALB/c mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In newborn BALB/c mice, thymosin alpha1 injections reduced the number of supraventricular amoeboid microglial cells by 37% compared with vehicle.

    In plain wordsIn newborn BALB/c mice, thymosin alpha1 injections lowered the number of microglial cells in the brain by 37% compared with vehicle.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseAmoeboid microglial cell number, BALB/c mice
    Study

    mousen: not reported in source

    Newborn athymic and BALB/c mice
    Comparator
    Vehicle injection
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Reduction in microglial cell number
    37%
    BALB/c mice

    Source sentences

    Summary
    a 37% reduction in BALB/c mice receiving thymosin alpha1 injections compared with those receiving vehicle injections.
    1 context sentence
    Summary · context
    The present study investigated the effects of intraperitoneal injections of thymosin alpha1 on the supraventricular amoeboid microglial cells (SAMC) in the newborn athymic and normal BALB/c mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In both BALB/c and athymic mice, thymosin alpha1 injections made some supraventricular amoeboid microglial cells ramified while the rest stayed amoeboid.

    In plain wordsIn mice, thymosin alpha1 injections changed some brain microglial cells to a branched shape; the rest kept their normal shape.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableMicroglial cell morphology
    Study

    mousen: not reported in source

    Newborn athymic and BALB/c mice
    Comparator
    Vehicle injection
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Some of the SAMC in both BALB/c and athymic mice receiving thymosin alpha1 injections became ramified, while the remainder still exhibited their normal amoeboid appearance with few filopodial processes.
    1 context sentence
    Summary · context
    The present study investigated the effects of intraperitoneal injections of thymosin alpha1 on the supraventricular amoeboid microglial cells (SAMC) in the newborn athymic and normal BALB/c mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In BALB/c mice, plasma cortisol was significantly higher 5 days after thymosin alpha1 injections than in controls.

    In plain wordsIn BALB/c mice, blood cortisol was higher 5 days after thymosin alpha1 injections than in control mice.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePlasma cortisol, BALB/c mice
    Study

    mousen: not reported in source

    Newborn athymic and BALB/c mice
    Comparator
    Vehicle injection
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Radioimmunoassay of the plasma of thymosin alpha1 and vehicle-injected mice showed that there was a significant increase in the cortisol level in BALB/c (P < 0.01)
    1 context sentence
    Summary · context
    The present study investigated the effects of intraperitoneal injections of thymosin alpha1 on the supraventricular amoeboid microglial cells (SAMC) in the newborn athymic and normal BALB/c mice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In athymic mice, plasma cortisol was significantly higher 5 days after thymosin alpha1 injections than in controls.

    In plain wordsIn athymic mice, blood cortisol was higher 5 days after thymosin alpha1 injections than in control mice.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePlasma cortisol, athymic mice
    Study

    mousen: not reported in source

    Newborn athymic and BALB/c mice
    Comparator
    Vehicle injection
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Radioimmunoassay of the plasma of thymosin alpha1 and vehicle-injected mice showed that there was a significant increase in the cortisol level in BALB/c (P < 0.01) and athymic (P < 0.001) mice 5 days after thymosin alpha1 injections, compared with that of the control mice.
    1 context sentence
    Summary · context
    The present study investigated the effects of intraperitoneal injections of thymosin alpha1 on the supraventricular amoeboid microglial cells (SAMC) in the newborn athymic and normal BALB/c mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c and athymic mice, some labelled microglial cells became slender or elongated after thymosin alpha1 injections, and their cytoplasm was reduced with fewer organelles.

    In plain wordsIn mice, thymosin alpha1 injections changed the shape of some brain microglial cells, which looked slimmer with fewer inner parts.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableMicroglial ultrastructure
    Study

    mousen: not reported in source

    Newborn athymic and BALB/c mice
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In both BALB/c and athymic mice, some labelled microglial cells became slender or elongated after thymosin alpha1 injections. Also their cytoplasm was reduced and contained fewer organelles.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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