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Study · Randomized controlled trial · n = 21 · 1997

5 results

Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism.

Pimentel-Filho FR, Ramos-Dias JC, Ninno FB, Façanha CF, Liberman B, Lengyel AM

Clinical endocrinology1 Mar 1997Cited by 5 (Europe PMC)

PMID9156038 (opens in a new tab)DOI10.1046/j.1365-2265.1997.1270942.x (opens in a new tab)PepBankPUB-09156038
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    The peak GH after GHRP‑6 alone did not differ significantly between patients with hypothyroidism and controls, despite a trend to smaller responses in patients.

    In plain wordsGHRP‑6 raised growth hormone to a similar level in people with an underactive thyroid and in controls, with a trend to smaller responses in patients.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak GH after GHRP-6, hypothyroid patients versus controls
    Study

    n = 21

    Comparator
    Control subjects
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    No significant differences in peak GH responses were observed following the administration of either GHRP-6 alone (controls 22.1 +/- 3.6; patients 12.6 +/- 1.9) or in combination with GHRH (controls 77.4 +/- 15.0; patients 52.8 +/- 10.9), despite the trend to smaller responses in hypothyroid patients.
    2 context sentences
    Summary · context
    Patients with hypothyroidism and normal controls were randomly submitted to 3 tests with GHRH (100 micrograms i.v.), GHRP-6 (1 microgram/kg i.v.) and GHRH + GHRP-6, on separate days.
    Summary · context
    Eleven patients with primary hypothyroidism were compared with 10 control subjects.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with primary hypothyroidism, GHRP‑6 produced a significantly higher peak GH than GHRH.

    In plain wordsIn people with an underactive thyroid, GHRP‑6 raised growth hormone more than GHRH did.

    Peptide
    GHRP-6
    Outcome
    IncreasePeak GH after GHRP-6 versus GHRH in hypothyroid patients
    Study

    n = 11

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    After GHRP-6 injection hypothyroid patients had a significantly higher GH release (12.6 +/- 1.9) than that obtained with GHRH, while in control subjects GH values were similar (22.1 +/- 3.6).
    2 context sentences
    Summary · context
    Patients with hypothyroidism and normal controls were randomly submitted to 3 tests with GHRH (100 micrograms i.v.), GHRP-6 (1 microgram/kg i.v.) and GHRH + GHRP-6, on separate days.
    Summary · context
    Eleven patients with primary hypothyroidism were compared with 10 control subjects.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In control subjects, the peak GH after GHRP‑6 was similar to that after GHRH.

    In plain wordsIn healthy controls, GHRP‑6 and GHRH raised growth hormone to a similar level.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak GH after GHRP-6 versus GHRH in control subjects
    Study

    n = 10

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    After GHRP-6 injection hypothyroid patients had a significantly higher GH release (12.6 +/- 1.9) than that obtained with GHRH, while in control subjects GH values were similar (22.1 +/- 3.6).
    2 context sentences
    Summary · context
    Patients with hypothyroidism and normal controls were randomly submitted to 3 tests with GHRH (100 micrograms i.v.), GHRP-6 (1 microgram/kg i.v.) and GHRH + GHRP-6, on separate days.
    Summary · context
    Eleven patients with primary hypothyroidism were compared with 10 control subjects.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 04HumanNot a test of GHRP-6 aloneRandomized controlled trialEfficacy outcome

    The peak GH after GHRP‑6 plus GHRH did not differ significantly between patients with hypothyroidism and controls, despite a trend to smaller responses in patients.

    In plain wordsGHRP‑6 with GHRH raised growth hormone to a similar level in people with an underactive thyroid and in controls.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak GH after GHRP-6 plus GHRH, hypothyroid patients versus controls
    Study

    n = 21

    Comparator
    Control subjects
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    No significant differences in peak GH responses were observed following the administration of either GHRP-6 alone (controls 22.1 +/- 3.6; patients 12.6 +/- 1.9) or in combination with GHRH (controls 77.4 +/- 15.0; patients 52.8 +/- 10.9), despite the trend to smaller responses in hypothyroid patients.
    2 context sentences
    Summary · context
    Patients with hypothyroidism and normal controls were randomly submitted to 3 tests with GHRH (100 micrograms i.v.), GHRP-6 (1 microgram/kg i.v.) and GHRH + GHRP-6, on separate days.
    Summary · context
    Eleven patients with primary hypothyroidism were compared with 10 control subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 05HumanNot a test of GHRP-6 aloneRandomized controlled trialEfficacy outcome

    In patients with primary hypothyroidism, adding GHRP‑6 to GHRH significantly increased the GH response.

    In plain wordsIn people with an underactive thyroid, giving GHRP‑6 with GHRH raised growth hormone more than GHRH alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response to GHRP-6 plus GHRH in hypothyroid patients
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    When GHRP-6 was associated with GHRH, a significant increase in the GH response was observed in these patients, which could suggest a role for somatostatin in this process.
    2 context sentences
    Summary · context
    Patients with hypothyroidism and normal controls were randomly submitted to 3 tests with GHRH (100 micrograms i.v.), GHRP-6 (1 microgram/kg i.v.) and GHRH + GHRP-6, on separate days.
    Summary · context
    Eleven patients with primary hypothyroidism were compared with 10 control subjects.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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