In MCF-7 breast cancer cells, EB1089 and 1,25(OH)2D3 did not inhibit the growth-promoting activity of long R3 IGF-I, although they attenuated that of IGF-I.
In plain wordsIn human breast cancer cells in a dish, vitamin D compounds did not block growth caused by long R3 IGF-I, but they did block IGF-I.
- Peptide
- IGF-1 LR3
- Outcome
- No significant changeGrowth-promoting activity of long R3 IGF-I with vitamin D compounds
- Study
humann: not reported in source
MCF-7 breast cancer cells- Outcome group
- Tumor growth · Cancer
Source sentences
EB1089 and 1,25(OH)2D3 attenuated the growth-promoting activity of insulin-like growth factor I on MCF-7 cells; however, these compounds did not inhibit the growth-promoting activity of long R3 IGF-I, an insulin-like growth factor I analogue with greatly reduced affinity for insulin-like growth factor-binding proteins.
1 context sentence(design, population, supporting numbers)
The human breast cancer cell line MCF-7 was used in this study.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.