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Study · Ex vivo tissue · mouse · 1997

5 results

Thymosin alpha 1 antagonizes dexamethasone and CD3-induced apoptosis of CD4+ CD8+ thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways.

Baumann CA, Badamchian M, Goldstein AL

Mechanisms of ageing and development1 Mar 1997Cited by 39 (Europe PMC)

PMID9147362 (opens in a new tab)DOI10.1016/s0047-6374(96)01860-x (opens in a new tab)PepBankPUB-09147362
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In murine thymocytes, thymosin alpha‑1 antagonized dexamethasone-induced and CD3-induced apoptosis of immature CD4+ CD8+ thymocytes.

    In plain wordsIn mouse thymus cells, thymosin alpha‑1 reduced cell death caused by dexamethasone or anti-CD3 in immature cells.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseApoptosis of CD4+ CD8+ thymocytes
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Comparator
    Dexamethasone or anti-CD3 alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Phenotypic analysis of the sub-populations of thymocytes, based on CD4 and CD8 expression, revealed that T alpha 1 exerts its effect on CD4+ CD8+ immature thymocytes.
    1 context sentence
    Title · context
    Thymosin alpha 1 antagonizes dexamethasone and CD3-induced apoptosis of CD4+ CD8+ thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways.
  2. 02LabEx vivo tissueMechanism

    In murine thymocytes, thymosin alpha‑1 delayed the production of free radicals observed during dexamethasone-induced and CD3-induced apoptosis.

    In plain wordsIn mouse thymus cells, thymosin alpha‑1 delayed the build-up of free radicals during induced cell death.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseFree radical production
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T alpha 1 treatment of thymocytes delays the production of free radicals
  3. 03LabEx vivo tissueMechanism

    In murine thymocytes, thymosin alpha‑1 delayed glutathione consumption observed during dexamethasone-induced and CD3-induced apoptosis.

    In plain wordsIn mouse thymus cells, thymosin alpha‑1 delayed the use of glutathione during induced cell death.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseGlutathione consumption
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and the subsequent consumption of glutathione, that is observed during both DEX and CD3 induced apoptosis.
  4. 04LabEx vivo tissueMechanism

    In murine thymocytes, thymosin alpha‑1 stimulated the production of cAMP.

    In plain wordsIn mouse thymus cells, thymosin alpha‑1 raised cAMP production.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasecAMP production
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further demonstrate that T alpha 1 stimulates the production of cAMP
  5. 05LabEx vivo tissueMechanism

    In murine thymocytes, thymosin alpha‑1 activated protein kinase C (PKC).

    In plain wordsIn mouse thymus cells, thymosin alpha‑1 activated protein kinase C.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseProtein kinase C activation
    Study

    mousen: not reported in source

    Murine thymocytes in vitro
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and activates PKC in thymocytes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

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