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Study · Non-randomized trial · n = 12 · 1997

3 results

High loading and low maintenance doses of a gonadotropin-releasing hormone antagonist effectively suppress serum luteinizing hormone, follicle-stimulating hormone, and testosterone in normal men.

Behre HM, Kliesch S, Pühse G, Reissmann T, Nieschlag E

The Journal of clinical endocrinology and metabolism1 May 1997Cited by 27 (Europe PMC)

PMID9141524 (opens in a new tab)DOI10.1210/jcem.82.5.3959 (opens in a new tab)PepBankPUB-09141524
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In young men, initial cetrorelix injections of 10 mg/day effectively suppressed LH, FSH and testosterone.

    In plain wordsIn young men, initial cetrorelix injections of 10 mg/day lowered LH, FSH and testosterone.

    Peptide
    Cetrorelix
    Outcome
    DecreaseInitial LH, FSH and testosterone suppression
    Study

    n = 12

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 mg/day · subcutaneous · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Initial injections of 10 mg/day cetrorelix suppressed LH, FSH, and T effectively.
    3 context sentences
    Summary · context
    Sixteen young male volunteers were randomly assigned to four study groups (n = 4/group).
    Summary · context
    Twelve men were injected s.c. with 10 mg cetrorelix at 0800 h for 5 days, followed by injections of 2 mg/day (group I), 2 x 1 mg/day (group II), and 1 mg/day (group III) up to the end of the 3-week injection period.
    Summary · context
    For the control, group IV was given daily placebo injections for 3 weeks.
  2. 02HumanNon-randomized trialEfficacy outcome

    In young men, lower cetrorelix maintenance doses maintained initial LH, FSH and testosterone suppression in all active groups.

    In plain wordsIn young men, lower cetrorelix maintenance doses maintained the initial decrease in LH, FSH and testosterone.

    Peptide
    Cetrorelix
    Outcome
    DecreaseMaintenance of LH, FSH and testosterone suppression
    Study

    n = 12

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    2 mg/day, 2 x 1 mg/day, or 1 mg/day after initial 10 mg dosing · subcutaneous · 3-week injection periodAs given in this study (human).

    Source sentences

    Summary
    This initial reduction of serum levels was maintained during the following low dose maintenance injections in all groups.
    3 context sentences
    Summary · context
    Twelve men were injected s.c. with 10 mg cetrorelix at 0800 h for 5 days, followed by injections of 2 mg/day (group I), 2 x 1 mg/day (group II), and 1 mg/day (group III) up to the end of the 3-week injection period.
    Summary · context
    Sixteen young male volunteers were randomly assigned to four study groups (n = 4/group).
    Summary · context
    For the control, group IV was given daily placebo injections for 3 weeks.
  3. 03HumanNon-randomized trialEfficacy outcome

    In young men, cetrorelix lowered LH, FSH and testosterone significantly further in weeks 2 and 3, near assay detection limits.

    In plain wordsIn young men, cetrorelix lowered LH, FSH and testosterone further in weeks 2 and 3 compared with initial suppression.

    Peptide
    Cetrorelix
    Outcome
    DecreaseFurther LH, FSH and testosterone suppression in weeks 2 and 3
    Study

    n = 12

    Comparator
    Initial suppression
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    2 mg/day, 2 x 1 mg/day, or 1 mg/day after initial 10 mg dosing · subcutaneous · 3-week injection periodAs given in this study (human).

    Source sentences

    Summary
    In comparison to the initial suppression, significantly lower levels of LH, FSH, and T near the assay detection limits were measured during study weeks 2 and 3.
    3 context sentences
    Summary · context
    Sixteen young male volunteers were randomly assigned to four study groups (n = 4/group).
    Summary · context
    Twelve men were injected s.c. with 10 mg cetrorelix at 0800 h for 5 days, followed by injections of 2 mg/day (group I), 2 x 1 mg/day (group II), and 1 mg/day (group III) up to the end of the 3-week injection period.
    Summary · context
    For the control, group IV was given daily placebo injections for 3 weeks.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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