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Study · Randomized controlled trial · n = 11 · 1997

3 results

Influence of endogenous cholinergic tone and growth hormone-releasing peptide-6 on exercise induced growth hormone release.

Nooitgedagt A, Koppeschaar HP, de Vries WR, Sidorowicz A, Klok LJ, Dieguez C, Mallo F, Mallo F

Clinical endocrinology1 Feb 1997Cited by 5 (Europe PMC)

PMID9135702 (opens in a new tab)DOI10.1046/j.1365-2265.1997.1080919.x (opens in a new tab)PepBankPUB-09135702
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, GHRP‑6 induced long lasting GH peaks with high amplitude, compared with the medium amplitude peaks of exercise alone and the low amplitude peaks of pyridostigmine.

    In plain wordsIn healthy men, GHRP‑6 caused long growth hormone peaks with high amplitude, higher than exercise alone or pyridostigmine.

    Peptide
    GHRP-6
    Outcome
    IncreaseAmplitude and duration of GH peaks after GHRP-6
    Study

    n = 11

    Comparator
    Exercise alone and pyridostigmine
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms · intravenousAs given in this study (human).

    Source sentences

    Summary
    GHRP-6 induced long lasting peaks with high amplitude
    3 context sentences
    Summary · context
    Exercise alone induced relatively short lasting peaks of medium amplitude, whereas PD induced long lasting peaks with low amplitudes.
    Summary · context
    Analysis of responses of serum GH to administration of pyridostigmine (PD, 120 mg, orally) or GHRP-6 (100 micrograms, i.v.), to exercise alone, and to the combinations of PD plus exercise or GHRP-6 plus exercise.
    Summary · context
    Eleven healthy, non-obese male subjects (age 23.9 +/- 0.3 years, body mass index 23 +/- 0.7 kg/m2, VO2 max: 52.4 +/- 2.0 ml/min/kg body weight; mean +/- SEM) participated in this study.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, GHRP‑6 plus exercise had additive effects on the amplitude of GH peaks.

    In plain wordsIn healthy men, adding GHRP‑6 to exercise raised growth hormone peaks more than either alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseAmplitude of GH peaks after GHRP-6 plus exercise
    Study

    n = 11

    Comparator
    Exercise alone and GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms · intravenousAs given in this study (human).

    Source sentences

    Summary
    GHRP-6 plus exercise also had additive effects on the amplitude.
    2 context sentences
    Summary · context
    Analysis of responses of serum GH to administration of pyridostigmine (PD, 120 mg, orally) or GHRP-6 (100 micrograms, i.v.), to exercise alone, and to the combinations of PD plus exercise or GHRP-6 plus exercise.
    Summary · context
    Eleven healthy, non-obese male subjects (age 23.9 +/- 0.3 years, body mass index 23 +/- 0.7 kg/m2, VO2 max: 52.4 +/- 2.0 ml/min/kg body weight; mean +/- SEM) participated in this study.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men, GHRP‑6 plus exercise increased the frequency of GH peaks.

    In plain wordsIn healthy men, adding GHRP‑6 to exercise made growth hormone peaks more frequent.

    Peptide
    GHRP-6
    Outcome
    IncreaseFrequency of GH peaks after GHRP-6 plus exercise
    Study

    n = 11

    Comparator
    Exercise alone and GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms · intravenousAs given in this study (human).

    Source sentences

    Summary
    The increase in frequency and amplitude of GH peaks, which occurred during the GHRP-6 plus exercise, indicates that exercise-induced GH release is not mediated through an increment in the release of an endogenous GHRP-6-like ligand, favouring the possibility that exercise-induced GH release is media…
    2 context sentences
    Summary · context
    Analysis of responses of serum GH to administration of pyridostigmine (PD, 120 mg, orally) or GHRP-6 (100 micrograms, i.v.), to exercise alone, and to the combinations of PD plus exercise or GHRP-6 plus exercise.
    Summary · context
    Eleven healthy, non-obese male subjects (age 23.9 +/- 0.3 years, body mass index 23 +/- 0.7 kg/m2, VO2 max: 52.4 +/- 2.0 ml/min/kg body weight; mean +/- SEM) participated in this study.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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