In isolated rat islets, des(1‑3) IGF-I with glucose immediately increased insulin release, which returned to control values within 30 minutes.
In plain wordsIn lab tests with rat islets, des(1‑3) IGF-I with glucose increased insulin release, which returned to control values within 30 minutes.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- IncreaseInsulin release after pulse exposure
- Study
ratn: not reported in source
Isolated adult rat islets of Langerhans- Comparator
- Control
- Outcome group
- Glycemic control · Endocrine and hormones
- Studied dose
- 13.3 nM · perifusionAs given in this study (rat).
Source sentences
Des(1-3) IGF-I (13.3 nM), which has a reduced binding affinity for IGF-binding proteins (IGFBPs), administered with 11.1 mM glucose caused an immediate increase in insulin release, which fell to control values within 30 min.
2 context sentences(design, population, supporting numbers)
Islets were isolated from adult male rats by collagenase digestion and Ficoll gradient separation, and were maintained in tissue culture for 48 h before perifusion.
Various doses (6.7-53 nM) of IGF-1, des(1-3) IGF-I or IGF-II were given either as a pulse between 30 and 35 min, or continuously from 30 to 90 min.