Effect of intranigral dosage with delta-sleep-inducing peptide and its analogs on movement and convulsive activity in rats.

Shandra AA, Godlevskii RS, Vast'yanov AI, Brusentsov AI, Mikhaleva II, Prudchenko IA, Zaporozhan VN

Neuroscience and behavioral physiology1 Nov 1996Cited by 3 (Europe PMC)

PMID9121635DOI10.1007/bf02359501PepBankPUB-09121635

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intranigral DSIP reduced horizontal movement activity in the open field.
In plain wordsIn rats, DSIP injected into the substantia nigra reduced horizontal movement.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseHorizontal movement activity
Study
ratn: not reported in source
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Studied dose
Dose not stated · intranigral microinjection into substantia nigra reticular partAs given in this study (rat).
Source sentences
Summary
Intranigral microinjection of DSIP, and of DSIP-1 and DSIP-4, reduced horizontal
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were carried out in rats on the effects of the administration of delta-sleep-inducing peptide (DSIP) and its analogs (1-4) into the reticular part of the substantia nigra on movement and convulsive activity.
Report a problemFND-0912163501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, intranigral DSIP reduced vertical movement activity in the open field.
In plain wordsIn rats, DSIP injected into the substantia nigra reduced vertical movement such as rearing.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseVertical movement activity
Study
ratn: not reported in source
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Studied dose
Dose not stated · intranigral microinjection into substantia nigra reticular partAs given in this study (rat).
Source sentences
Summary
Intranigral microinjection of DSIP, and of DSIP-1 and DSIP-4, reduced horizontal and vertical movement activity as well as excursions to the center of the open field.
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were carried out in rats on the effects of the administration of delta-sleep-inducing peptide (DSIP) and its analogs (1-4) into the reticular part of the substantia nigra on movement and convulsive activity.
Report a problemFND-0912163502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, intranigral DSIP reduced excursions to the center of the open field.
In plain wordsIn rats, DSIP injected into the substantia nigra reduced trips to the center of the open field.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseExcursions to the center of the open field
Study
ratn: not reported in source
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Studied dose
Dose not stated · intranigral microinjection into substantia nigra reticular partAs given in this study (rat).
Source sentences
Summary
Intranigral microinjection of DSIP, and of DSIP-1 and DSIP-4, reduced horizontal and vertical movement activity as well as excursions to the center of the open field.
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were carried out in rats on the effects of the administration of delta-sleep-inducing peptide (DSIP) and its analogs (1-4) into the reticular part of the substantia nigra on movement and convulsive activity.
Report a problemFND-0912163503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, intranigral DSIP increased the latent period of the first picrotoxin-induced convulsion.
In plain wordsIn rats, DSIP injected into the substantia nigra delayed the first convulsion caused by picrotoxin.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseLatent period of first picrotoxin-induced convulsion
Study
ratn: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intranigral microinjection into substantia nigra reticular partAs given in this study (rat).
Source sentences
Summary
DSIP, DSIP-2, and DSIP-3 had anticonvulsant effects, consisting of increases in the latent periods of the first convulsion and clonicotonic convulsions induced by picrotoxin, and reductions in the mean intensity of convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were carried out in rats on the effects of the administration of delta-sleep-inducing peptide (DSIP) and its analogs (1-4) into the reticular part of the substantia nigra on movement and convulsive activity.
Report a problemFND-0912163504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, intranigral DSIP increased the latent period of picrotoxin-induced clonicotonic convulsions.
In plain wordsIn rats, DSIP injected into the substantia nigra delayed clonicotonic convulsions caused by picrotoxin.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseLatent period of clonicotonic convulsions
Study
ratn: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intranigral microinjection into substantia nigra reticular partAs given in this study (rat).
Source sentences
Summary
DSIP, DSIP-2, and DSIP-3 had anticonvulsant effects, consisting of increases in the latent periods of the first convulsion and clonicotonic convulsions induced by picrotoxin, and reductions in the mean intensity of convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were carried out in rats on the effects of the administration of delta-sleep-inducing peptide (DSIP) and its analogs (1-4) into the reticular part of the substantia nigra on movement and convulsive activity.
Report a problemFND-0912163505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, intranigral DSIP reduced the mean intensity of picrotoxin-induced convulsions.
In plain wordsIn rats, DSIP injected into the substantia nigra made picrotoxin-induced convulsions less intense.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseMean intensity of picrotoxin-induced convulsions
Study
ratn: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intranigral microinjection into substantia nigra reticular partAs given in this study (rat).
Source sentences
Summary
DSIP, DSIP-2, and DSIP-3 had anticonvulsant effects, consisting of increases in the latent periods of the first convulsion and clonicotonic convulsions induced by picrotoxin, and reductions in the mean intensity of convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were carried out in rats on the effects of the administration of delta-sleep-inducing peptide (DSIP) and its analogs (1-4) into the reticular part of the substantia nigra on movement and convulsive activity.
Report a problemFND-0912163506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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