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Study · Not a test of the peptide alone · 1997

5 results

Increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2',4',6'-trichlorobiphenyl is estrogen receptor mediated.

Tsai ML, Webb RC, Loch-Caruso R

Biology of reproduction1 Feb 1997Cited by 10 (Europe PMC)

PMID9116132 (opens in a new tab)DOI10.1095/biolreprod56.2.341 (opens in a new tab)PepBankPUB-09116132
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In midgestation rat uterine explants, 20 h of exposure to 4-OH-TCB did not change the contractile response to oxytocin.

    In plain wordsIn lab tests on rat uterine tissue, 20 hours of 4-OH-TCB did not change how strongly the tissue contracted to oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin-induced contraction after 20 h 4-OH-TCB
    Study

    ratn: not reported in source

    midgestation rat uterine explants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    A 20-h exposure to either 4-OH-TCB (0.1, 1, or 10 microM) or estradiol-17beta (10 nM) failed to alter the contractile response to cumulative additions of oxytocin (10(-10) to 10(-7) M).
    1 context sentence
    Summary · context
    After in vitro treatments with 4-OH-TCB or estradiol-17beta for 20 h or 42 h, uterine explants from midgestation rats were mounted in standard muscle baths for measurement of isometric contractions.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In midgestation rat uterine explants, 20 h of exposure to estradiol-17beta did not change the contractile response to oxytocin.

    In plain wordsIn lab tests on rat uterine tissue, 20 hours of estradiol did not change how strongly the tissue contracted to oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin-induced contraction after 20 h estradiol-17beta
    Study

    ratn: not reported in source

    midgestation rat uterine explants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    A 20-h exposure to either 4-OH-TCB (0.1, 1, or 10 microM) or estradiol-17beta (10 nM) failed to alter the contractile response to cumulative additions of oxytocin (10(-10) to 10(-7) M).
    1 context sentence
    Summary · context
    After in vitro treatments with 4-OH-TCB or estradiol-17beta for 20 h or 42 h, uterine explants from midgestation rats were mounted in standard muscle baths for measurement of isometric contractions.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In midgestation rat uterine explants, 42 h of exposure to 1 microM 4-OH-TCB significantly increased the contractile response to oxytocin.

    In plain wordsIn lab tests on rat uterine tissue, 42 hours of 4-OH-TCB made the tissue contract more strongly to oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin-induced contraction after 42 h 4-OH-TCB
    Study

    ratn: not reported in source

    midgestation rat uterine explants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    However, a 42-h exposure to either 1 microM 4-OH-TCB or 10 nM estradiol-17beta significantly elevated the contractile response to oxytocin, which was abolished by cotreatment with the estrogen receptor antagonist tamoxifen (30 nM).
    1 context sentence
    Summary · context
    After in vitro treatments with 4-OH-TCB or estradiol-17beta for 20 h or 42 h, uterine explants from midgestation rats were mounted in standard muscle baths for measurement of isometric contractions.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In midgestation rat uterine explants, 42 h of exposure to 10 nM estradiol-17beta significantly increased the contractile response to oxytocin.

    In plain wordsIn lab tests on rat uterine tissue, 42 hours of estradiol made the tissue contract more strongly to oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin-induced contraction after 42 h estradiol-17beta
    Study

    ratn: not reported in source

    midgestation rat uterine explants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    However, a 42-h exposure to either 1 microM 4-OH-TCB or 10 nM estradiol-17beta significantly elevated the contractile response to oxytocin, which was abolished by cotreatment with the estrogen receptor antagonist tamoxifen (30 nM).
    1 context sentence
    Summary · context
    After in vitro treatments with 4-OH-TCB or estradiol-17beta for 20 h or 42 h, uterine explants from midgestation rats were mounted in standard muscle baths for measurement of isometric contractions.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  5. 05LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In midgestation rat uterine explants, the estrogen receptor antagonist tamoxifen abolished the increased oxytocin contractile response caused by 4-OH-TCB or estradiol-17beta.

    In plain wordsIn lab tests on rat uterine tissue, the estrogen blocker tamoxifen removed the extra contraction caused by 4-OH-TCB or estradiol.

    Peptide
    Oxytocin
    Outcome
    DecreaseEffect of tamoxifen on 42 h enhancement of oxytocin response
    Study

    ratn: not reported in source

    midgestation rat uterine explants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    However, a 42-h exposure to either 1 microM 4-OH-TCB or 10 nM estradiol-17beta significantly elevated the contractile response to oxytocin, which was abolished by cotreatment with the estrogen receptor antagonist tamoxifen (30 nM).
    1 context sentence
    Summary · context
    After in vitro treatments with 4-OH-TCB or estradiol-17beta for 20 h or 42 h, uterine explants from midgestation rats were mounted in standard muscle baths for measurement of isometric contractions.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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