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Study · In vitro (cells) · rat · 1997

2 results

Effects of insulin and insulin-like growth factors on proliferation of rat ovarian theca-interstitial cells.

Duleba AJ, Spaczynski RZ, Olive DL, Behrman HR

Biology of reproduction1 Apr 1997Cited by 67 (Europe PMC)

PMID9096870 (opens in a new tab)DOI10.1095/biolreprod56.4.891 (opens in a new tab)PepBankPUB-09096870
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In rat theca-interstitial cells, long R3 IGF-I produced greater effects on DNA synthesis than IGF-I.

    In plain wordsIn rat ovarian cells in a dish, long R3 IGF-I raised DNA synthesis more than regular IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseDNA synthesis (thymidine incorporation)
    Study

    ratn: not reported in source

    purified rat theca-interstitial cells
    Comparator
    IGF-I
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I mutants with decreased affinity to IGF-binding proteins (IGFBPs)-long R3-IGF-I and des(1-3)IGF-I-produced greater effects on DNA synthesis than did IGF-I.
    1 context sentence
    Summary · context
    This study was an investigation of the effects of insulin and insulin-like growth factors (IGF-I and IGF-II) on proliferation of rat T-I cells.
  2. 02LabIn vitro (cells)Activity measurement

    In rat ovarian theca-interstitial cells, des(1‑3)IGF-I stimulated DNA synthesis more than IGF-I.

    In plain wordsIn cells from rats, des(1‑3)IGF-I increased DNA synthesis more than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseDNA synthesis
    Study

    ratn: not reported in source

    Ovarian theca-interstitial cells
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I mutants with decreased affinity to IGF-binding proteins (IGFBPs)-long R3-IGF-I and des(1-3)IGF-I-produced greater effects on DNA synthesis than did IGF-I.
    2 context sentences
    Summary · context
    This study was an investigation of the effects of insulin and insulin-like growth factors (IGF-I and IGF-II) on proliferation of rat T-I cells.
    Summary · context
    Purified T-I cells were incubated in chemically defined media.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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