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Study · In vitro (cells) · rat · 1997

8 results

Growth hormone releasing peptides: a comparison of the growth hormone releasing activities of GHRP-2 and GHRP-6 in rat primary pituitary cells.

Cheng J, Wu TJ, Butler B, Cheng K

Life sciences1 Jan 1997Cited by 13 (Europe PMC)

PMID9096259 (opens in a new tab)DOI10.1016/s0024-3205(96)00655-8 (opens in a new tab)PepBankPUB-09096259
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat primary pituitary cells, GHRP‑2 acted synergistically with GRF to release GH.

    In plain wordsIn rat pituitary cells in lab tests, GHRP‑2 and GRF together released more growth hormone than expected from either alone.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH release with GRF (synergy)
    Study

    ratn: not reported in source

    Primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the rat system, GHRP-2, like GHRP-6, acts synergistically with GRF to release GH.
    1 context sentence
    Summary · context
    In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6.
  2. 02LabIn vitro (cells)Mechanism

    In rat primary pituitary cells, the GH-releasing effect of GHRP‑2 was inhibited by Peptide Antagonist.

    In plain wordsIn rat pituitary cells in lab tests, a peptide antagonist blocked the growth hormone release caused by GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2 effect with Peptide Antagonist
    Study

    ratn: not reported in source

    Primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effect of GHRP-2 was inhibited by Peptide Antagonist
    1 context sentence
    Summary · context
    In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6.
  3. 03LabIn vitro (cells)Mechanism

    In rat primary pituitary cells, the GH-releasing effect of GHRP‑2 was not affected by a GRF antagonist.

    In plain wordsIn rat pituitary cells in lab tests, a GRF blocker did not change the growth hormone release caused by GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    No significant changeGHRP-2 effect with GRF antagonist
    Study

    ratn: not reported in source

    Primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but was not affected by a GRF antagonist.
    1 context sentence
    Summary · context
    In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6.

Studies that did not test the peptide alone5

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 04LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat primary pituitary cells, GHRP‑6 acted synergistically with GRF to release GH.

    In plain wordsIn rat pituitary cells, GHRP‑6 and GRF together released more growth hormone than expected from each alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseSynergy of GHRP-6 with GRF on GH release
    Study

    ratn: not reported in source

    rat primary pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In the rat system, GHRP-2, like GHRP-6, acts synergistically with GRF to release GH.
    1 context sentence
    Summary · context
    In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 05LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat primary pituitary cells, GHRP-2 and GHRP‑6 together at maximal concentrations released no more GH than either one alone.

    In plain wordsIn rat pituitary cells, using GHRP-2 and GHRP‑6 together released no more growth hormone than either one alone.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH release with GHRP-2 and GHRP-6 together at maximal concentrations
    Study

    ratn: not reported in source

    rat primary pituitary cells
    Comparator
    GHRP-2 alone or GHRP-6 alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Co-administration of GHRP-2 and GHRP-6 at maximal concentrations had no further effect on GH release than either one alone.
    1 context sentence
    Summary · context
    In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 06LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat primary pituitary cells, the GHRPs desensitized cells to each other but not to GRF.

    In plain wordsIn rat pituitary cells, the growth hormone-releasing peptides made cells less responsive to each other but not to GRF.

    Peptide
    GHRP-6
    Outcome
    MixedDesensitization of cells by GHRPs
    Study

    ratn: not reported in source

    rat primary pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The GHRP's were able to desensitize cells to each other, but not to GRF.
    1 context sentence
    Summary · context
    In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 07LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In rat primary pituitary cells, co-administration of GHRP‑2 and GHRP-6 at maximal concentrations had no further effect on GH release than either one alone.

    In plain wordsIn rat pituitary cells in lab tests, giving GHRP‑2 and GHRP-6 together released no more growth hormone than either alone.

    Peptide
    GHRP-2
    Outcome
    No significant changeGH release with GHRP-2 plus GHRP-6
    Study

    ratn: not reported in source

    Primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Co-administration of GHRP-2 and GHRP-6 at maximal concentrations had no further effect on GH release than either one alone.
    1 context sentence
    Summary · context
    In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  5. 08LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In rat primary pituitary cells, the GHRPs (GHRP‑2 and GHRP-6) desensitized cells to each other but not to GRF.

    In plain wordsIn rat pituitary cells in lab tests, GHRP‑2 and GHRP-6 made cells less responsive to each other, but not to GRF.

    Peptide
    GHRP-2
    Outcome
    MixedCross-desensitization to GHRPs and GRF
    Study

    ratn: not reported in source

    Primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The GHRP's were able to desensitize cells to each other, but not to GRF.
    1 context sentence
    Summary · context
    In the present study, the effect of GHRP-2 on GH release was evaluated in rat primary pituitary cells, and the results were compared with those elicited by GHRP-6.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 12:58 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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