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Study · In vitro (cells) · rat · 1997

1 result

Substance P increases intracellular Ca2+ in individual rat pituitary lactotrophs, somatotrophs, and gonadotrophs.

Mau SE, Witt MR, Saermark T, Vilhardt H

Molecular and cellular endocrinology1 Feb 1997Cited by 8 (Europe PMC)

PMID9089657 (opens in a new tab)DOI10.1016/s0303-7207(96)03988-3 (opens in a new tab)PepBankPUB-09089657
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In rat somatotrophs, growth hormone-releasing hexapeptide produced a greater maximal intracellular calcium response than substance P.

    In plain wordsIn rat pituitary cells, growth hormone-releasing hexapeptide produced a greater maximum calcium response than substance P.

    Peptide
    GHRP-6
    Outcome
    IncreaseMaximal intracellular calcium response
    Study

    ratn: not reported in source

    Somatotrophs from male peripubertal rats
    Comparator
    Substance P
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These experiments demonstrated that SP was a weaker agonist in terms of maximal [Ca2+]i response than thyrotropin-releasing hormone (TRH) (in lactotrophs), growth hormone-releasing hexapeptide (in somatotrophs) and GnRH (in gonadotrophs).
    1 context sentence
    Summary · context
    On the basis of these results it is concluded that SP exerts direct Ca2+ mobilizing effects in single lactotrophs, somatotrophs, and gonadotrophs derived from male peripubertal rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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