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Study · Animal study (in vivo) · rat · 1997

5 results

Physiological effects and brain protection by hypothermia and cerebrolysin after moderate forebrain ischemia in rats.

Schwab M, Bauer R, Zwiener U

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie1 Feb 1997Cited by 14 (Europe PMC)

PMID9085084 (opens in a new tab)DOI10.1016/s0940-2993(97)80078-4 (opens in a new tab)PepBankPUB-09085084
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with forebrain ischemia, Cerebrolysin prevented brain edema under normothermic conditions compared with untreated rats.

    In plain wordsIn rats with forebrain ischemia, Cerebrolysin prevented brain edema under normal temperature conditions compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain edema under normothermia
    Study

    ratn: not reported in source

    Adult Wistar rats with bilateral carotid artery ligation
    Comparator
    Normothermic untreated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin prevented the development of brain edema, too, both under normo- and hypothermic conditions.
    1 context sentence
    Summary · context
    Four groups of adult Wistar rats (untreated and Cerebrolysin treated animals with 35 degrees C and 37 degrees C rectal temperature) were subjected to moderate forebrain ischemia by permanent bilateral carotid artery ligation for 6 h.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with forebrain ischemia, Cerebrolysin prevented brain edema under hypothermic conditions compared with untreated rats.

    In plain wordsIn rats with forebrain ischemia, Cerebrolysin prevented brain edema under reduced temperature conditions compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain edema under hypothermia
    Study

    ratn: not reported in source

    Adult Wistar rats with bilateral carotid artery ligation
    Comparator
    Hypothermic untreated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin prevented the development of brain edema, too, both under normo- and hypothermic conditions.
    1 context sentence
    Summary · context
    Four groups of adult Wistar rats (untreated and Cerebrolysin treated animals with 35 degrees C and 37 degrees C rectal temperature) were subjected to moderate forebrain ischemia by permanent bilateral carotid artery ligation for 6 h.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with forebrain ischemia, Cerebrolysin with hypothermia restored higher occipital cortical blood flow than hypothermia alone.

    In plain wordsIn rats with forebrain ischemia, Cerebrolysin with hypothermia restored higher occipital blood flow than hypothermia alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseOccipital cortical blood flow versus hypothermic controls
    Study

    ratn: not reported in source

    Adult Wistar rats with bilateral carotid artery ligation
    Comparator
    Hypothermic untreated rats
    Outcome group
    Vascular function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The ICBF was restored to higher levels in the occipital cortex in comparison both to the normothermic Cerebrolysin treated and hypothermic untreated rats (p < 0.05).
    1 context sentence
    Summary · context
    Four groups of adult Wistar rats (untreated and Cerebrolysin treated animals with 35 degrees C and 37 degrees C rectal temperature) were subjected to moderate forebrain ischemia by permanent bilateral carotid artery ligation for 6 h.

Studies that did not test the peptide alone2

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome

    In rats with forebrain ischemia, Cerebrolysin with hypothermia restored higher occipital cortical blood flow than Cerebrolysin under normothermia.

    In plain wordsIn rats with forebrain ischemia, Cerebrolysin with hypothermia restored higher occipital blood flow than Cerebrolysin under normal temperature conditions.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseOccipital cortical blood flow versus normothermic Cerebrolysin
    Study

    ratn: not reported in source

    Adult Wistar rats with bilateral carotid artery ligation
    Comparator
    Normothermic Cerebrolysin-treated rats
    Outcome group
    Vascular function · Nervous system and cognition

    Source sentences

    Summary
    The ICBF was restored to higher levels in the occipital cortex in comparison both to the normothermic Cerebrolysin treated and hypothermic untreated rats (p < 0.05).
    1 context sentence
    Summary · context
    Four groups of adult Wistar rats (untreated and Cerebrolysin treated animals with 35 degrees C and 37 degrees C rectal temperature) were subjected to moderate forebrain ischemia by permanent bilateral carotid artery ligation for 6 h.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  2. 05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Activity measurement

    In rats with forebrain ischemia, the blood-flow effect of Cerebrolysin with hypothermia was associated with only slight ECoG changes.

    In plain wordsIn rats with forebrain ischemia, Cerebrolysin with hypothermia showed a blood-flow effect associated with only slight brain electrical changes.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedECoG changes
    Study

    ratn: not reported in source

    Adult Wistar rats with bilateral carotid artery ligation
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This effect of Cerebrolysin was associated with only slight changes in ECoG, indicating that the neuronal activity state and the energy supply was obviously not decisively influenced.
    1 context sentence
    Summary · context
    Four groups of adult Wistar rats (untreated and Cerebrolysin treated animals with 35 degrees C and 37 degrees C rectal temperature) were subjected to moderate forebrain ischemia by permanent bilateral carotid artery ligation for 6 h.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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