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Study · Animal study (in vivo) · rat · 1997

6 results

Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats--protective effects of Cerebrolysin.

Schwab M, Schaller R, Bauer R, Zwiener U

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie1 Feb 1997Cited by 14 (Europe PMC)

PMID9085071 (opens in a new tab)DOI10.1016/s0940-2993(97)80053-x (opens in a new tab)PepBankPUB-09085071
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rats after carotid ligation, Cerebrolysin reduced early mortality versus untreated controls (4 out of 20 versus 20 out of 63).

    In plain wordsIn rats after carotid ligation, Cerebrolysin reduced early mortality compared with untreated controls.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseEarly mortality after carotid ligation
    Study

    ratn: not reported in source

    Adult Wistar rats after permanent bilateral carotid artery ligation
    Comparator
    Untreated controls
    Outcome group
    Mortality · Whole body
    Studied dose
    2.5 ml/kg body weight · s.c.As given in this study (rat).

    Measurements

    Deaths
    4 animals
    Cerebrolysin
    Mortality
    16.7%
    Cerebrolysin
    Deaths
    20 animals
    Untreated control
    Mortality
    31.7%
    Untreated control

    Source sentences

    Summary
    After permanent carotid artery ligation, 20 out of 63 (31.7%) untreated control animals died within 24 h but only 4 out of 20 (16.7%) Cerebrolysin treated animals.
    1 context sentence
    Summary · context
    Morphofunctional effects of combined moderate forebrain ischemia due to permanent bilateral carotid artery ligation and short-term systemic hypoxia in rats were investigated.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In rats with forebrain ischemia, Cerebrolysin had no detectable effect on mortality after additional acute hypoxia.

    In plain wordsIn rats with forebrain ischemia, Cerebrolysin had no detectable effect on mortality after additional acute hypoxia.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeMortality after additional hypoxia
    Study

    ratn: not reported in source

    Adult Wistar rats with forebrain ischemia and hypoxia
    Comparator
    Physiological saline
    Outcome group
    Mortality · Whole body
    Studied dose
    2.5 ml/kg body weight · s.c.As given in this study (rat).

    Source sentences

    Summary
    However, Cerebrolysin had not detectable effect on mortality after the additional acute hypoxia.
    1 context sentence
    Summary · context
    Morphofunctional effects of combined moderate forebrain ischemia due to permanent bilateral carotid artery ligation and short-term systemic hypoxia in rats were investigated.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ischemia and hypoxia, Cerebrolysin showed no protective effect on behavior compared with saline controls.

    In plain wordsIn rats with ischemia and hypoxia, Cerebrolysin showed no protective effect on behavior compared with saline controls.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeBehavior after hypoxia
    Study

    ratn: not reported in source

    Adult Wistar rats with forebrain ischemia and hypoxia
    Comparator
    Physiological saline
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    2.5 ml/kg body weight · s.c.As given in this study (rat).

    Source sentences

    Summary
    We did not observe a relationship between behavior, ECoG depression and the extent of morphological damage after hypoxia nor did we find any protective effects of Cerebrolysin on these parameters.
    1 context sentence
    Summary · context
    Morphofunctional effects of combined moderate forebrain ischemia due to permanent bilateral carotid artery ligation and short-term systemic hypoxia in rats were investigated.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In rats with ischemia and hypoxia, Cerebrolysin showed no protective effect on ECoG depression compared with saline controls.

    In plain wordsIn rats with ischemia and hypoxia, Cerebrolysin showed no protective effect on brain electrical depression compared with saline controls.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeECoG depression after hypoxia
    Study

    ratn: not reported in source

    Adult Wistar rats with forebrain ischemia and hypoxia
    Comparator
    Physiological saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg body weight · s.c.As given in this study (rat).

    Source sentences

    Summary
    We did not observe a relationship between behavior, ECoG depression and the extent of morphological damage after hypoxia nor did we find any protective effects of Cerebrolysin on these parameters.
    1 context sentence
    Summary · context
    Morphofunctional effects of combined moderate forebrain ischemia due to permanent bilateral carotid artery ligation and short-term systemic hypoxia in rats were investigated.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ischemia and hypoxia, Cerebrolysin showed no protective effect on morphological brain damage compared with saline controls.

    In plain wordsIn rats with ischemia and hypoxia, Cerebrolysin showed no protective effect on brain damage compared with saline controls.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeMorphological brain damage after hypoxia
    Study

    ratn: not reported in source

    Adult Wistar rats with forebrain ischemia and hypoxia
    Comparator
    Physiological saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg body weight · s.c.As given in this study (rat).

    Source sentences

    Summary
    We did not observe a relationship between behavior, ECoG depression and the extent of morphological damage after hypoxia nor did we find any protective effects of Cerebrolysin on these parameters.
    1 context sentence
    Summary · context
    Morphofunctional effects of combined moderate forebrain ischemia due to permanent bilateral carotid artery ligation and short-term systemic hypoxia in rats were investigated.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, basal reflex responses did not change in any group, including Cerebrolysin-treated animals, after hypoxia.

    In plain wordsIn rats, basal reflex responses did not change in any group, including Cerebrolysin-treated animals, after hypoxia.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeBasal reflex responses after hypoxia
    Study

    ratn: not reported in source

    Forebrain ischemia with additional hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg body weight · s.c.As given in this study (rat).

    Source sentences

    Summary
    All animals showed reduced behavioral activity (p < 0.01) 20 min after hypoxia, however, basal reflex responses were not altered.
    3 context sentences
    Summary · context
    A first group (19 out of 56 animals) received Cerebrolysin (every dose 2.5 ml/kg body weight s.c.) after ligation, after hypoxia and then daily.
    Summary · context
    A second group (6 out of 56 animals) received an equal volume of physiological saline after ligation and Cerebrolysin the first time after hypoxia and then once a day.
    Summary · context
    An untreated control group (31 out 56 animals) received physiological saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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