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Study · Animal study (in vivo) · rat · 1997

8 results

Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats.

Thomas GB, Fairhall KM, Robinson IC

Endocrinology1 Apr 1997Cited by 62 (Europe PMC)

PMID9075719 (opens in a new tab)DOI10.1210/endo.138.4.5065 (opens in a new tab)PepBankPUB-09075719
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In conscious rats, ACTH responses to GHRP‑6 varied with prevailing hypothalamo-pituitary-adrenal activity.

    In plain wordsIn rats, ACTH responses to GHRP‑6 varied with the activity of the stress hormone system.

    Peptide
    GHRP-6
    Outcome
    MixedACTH response
    Study

    ratn: not reported in source

    Conscious rats
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    10 microg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    CRH and AVP increased plasma ACTH levels in all rats, whereas ACTH and corticosterone responses to GHRP-6 were variable and were dependent on the prevailing activity of the hypothalamo-pituitary-adrenal axis.
    2 context sentences
    Summary · context
    We have now examined the activation of the hypothalamo-pituitary-adrenal axis by GHRP-6 in conscious rats.
    Summary · context
    In a series of experiments, rats were injected i.v. with 10 microg GHRP-6, 2 microg CRH, 0.5 microg AVP, or saline, alone or in combination, and serial plasma samples withdrawn and assayed for ACTH, corticosterone, and GH.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In conscious rats, corticosterone responses to GHRP‑6 varied with prevailing hypothalamo-pituitary-adrenal activity.

    In plain wordsIn rats, corticosterone responses to GHRP‑6 varied with the activity of the stress hormone system.

    Peptide
    GHRP-6
    Outcome
    MixedCorticosterone response
    Study

    ratn: not reported in source

    Conscious rats
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    10 microg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    CRH and AVP increased plasma ACTH levels in all rats, whereas ACTH and corticosterone responses to GHRP-6 were variable and were dependent on the prevailing activity of the hypothalamo-pituitary-adrenal axis.
    2 context sentences
    Summary · context
    We have now examined the activation of the hypothalamo-pituitary-adrenal axis by GHRP-6 in conscious rats.
    Summary · context
    In a series of experiments, rats were injected i.v. with 10 microg GHRP-6, 2 microg CRH, 0.5 microg AVP, or saline, alone or in combination, and serial plasma samples withdrawn and assayed for ACTH, corticosterone, and GH.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In rats, GHRP‑6 stimulated the largest ACTH responses when basal ACTH and corticosterone were lowest.

    In plain wordsIn rats, GHRP‑6 produced larger ACTH responses when initial ACTH and corticosterone levels were lower.

    Peptide
    GHRP-6
    Outcome
    IncreaseACTH response by basal hormone activity
    Study

    ratn: not reported in source

    Conscious rats
    Comparator
    Rats with higher basal ACTH and corticosterone
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    10 microg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 stimulated the largest ACTH responses in rats that had the lowest basal plasma ACTH and corticosterone levels before GHRP-6 administration.
    2 context sentences
    Summary · context
    We have now examined the activation of the hypothalamo-pituitary-adrenal axis by GHRP-6 in conscious rats.
    Summary · context
    In a series of experiments, rats were injected i.v. with 10 microg GHRP-6, 2 microg CRH, 0.5 microg AVP, or saline, alone or in combination, and serial plasma samples withdrawn and assayed for ACTH, corticosterone, and GH.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In rats, adding GHRP‑6 to CRH did not increase ACTH beyond the CRH-alone response.

    In plain wordsIn rats, GHRP‑6 plus CRH did not raise ACTH more than CRH alone.

    Peptide
    GHRP-6
    Outcome
    No significant changeACTH response added to CRH
    Study

    ratn: not reported in source

    Conscious rats
    Comparator
    CRH alone
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    10 microg · intravenousAs given in this study (rat).

    Measurements

    ACTH change
    1570 pg/ml
    GHRP-6 plus CRH
    ACTH change
    1714 pg/ml
    CRH alone

    Source sentences

    Summary
    GHRP-6 given in combination with CRH did not increase ACTH levels beyond the response to CRH alone (change in ACTH, 1570 +/- 207 vs. 1714 +/- 245 pg/ml)
    2 context sentences
    Summary · context
    We have now examined the activation of the hypothalamo-pituitary-adrenal axis by GHRP-6 in conscious rats.
    Summary · context
    In a series of experiments, rats were injected i.v. with 10 microg GHRP-6, 2 microg CRH, 0.5 microg AVP, or saline, alone or in combination, and serial plasma samples withdrawn and assayed for ACTH, corticosterone, and GH.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In rats, adding GHRP‑6 to AVP increased ACTH compared with AVP alone.

    In plain wordsIn rats, GHRP‑6 plus AVP raised ACTH more than AVP alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseACTH response added to AVP
    Study

    ratn: not reported in source

    Conscious rats
    Comparator
    AVP alone
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    10 microg · intravenousAs given in this study (rat).

    Measurements

    ACTH change
    5587 pg/ml
    GHRP-6 plus AVP
    ACTH change
    2338 pg/ml
    AVP alone

    Source sentences

    Summary
    whereas the combination of GHRP-6 and AVP markedly increased ACTH levels compared with the effects of AVP alone (change in ACTH, 5587 +/- 669 vs. 2338 +/- 451 pg/ml; P < 0.05).
    2 context sentences
    Summary · context
    We have now examined the activation of the hypothalamo-pituitary-adrenal axis by GHRP-6 in conscious rats.
    Summary · context
    In a series of experiments, rats were injected i.v. with 10 microg GHRP-6, 2 microg CRH, 0.5 microg AVP, or saline, alone or in combination, and serial plasma samples withdrawn and assayed for ACTH, corticosterone, and GH.
  6. 06AnimalAnimal study (in vivo)Activity measurement

    In rats, GH responses to GHRP‑6 were greater with low basal ACTH and corticosterone than with elevated levels.

    In plain wordsIn rats, GHRP‑6 produced greater growth hormone responses with low initial ACTH and corticosterone than with elevated levels.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response by basal stress hormone activity
    Study

    ratn: not reported in source

    Conscious rats
    Comparator
    Rats with elevated basal ACTH and corticosterone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 microg · intravenousAs given in this study (rat).

    Measurements

    GH response change
    119 ng/ml
    low basal ACTH and corticosterone
    GH response change
    29 ng/ml
    elevated ACTH and corticosterone

    Source sentences

    Summary
    The GH responses to GHRP-6 were significantly greater in rats with low basal plasma ACTH and corticosterone levels than in rats with elevated ACTH and corticosterone levels (change in GH response, 119 +/- 27 vs. 29 +/- 7 ng/ml; P < 0.01).
    2 context sentences
    Summary · context
    We have now examined the activation of the hypothalamo-pituitary-adrenal axis by GHRP-6 in conscious rats.
    Summary · context
    In a series of experiments, rats were injected i.v. with 10 microg GHRP-6, 2 microg CRH, 0.5 microg AVP, or saline, alone or in combination, and serial plasma samples withdrawn and assayed for ACTH, corticosterone, and GH.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 07AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement

    In rats, CRH did not affect the GH response to GHRP‑6.

    In plain wordsIn rats, CRH did not change the growth hormone response to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    No significant changeCRH effect on GHRP-6-induced GH response
    Study

    ratn: not reported in source

    Conscious rats
    Comparator
    GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Neither CRH nor AVP had any effect on the GH response to GHRP-6.
    2 context sentences
    Summary · context
    We have now examined the activation of the hypothalamo-pituitary-adrenal axis by GHRP-6 in conscious rats.
    Summary · context
    In a series of experiments, rats were injected i.v. with 10 microg GHRP-6, 2 microg CRH, 0.5 microg AVP, or saline, alone or in combination, and serial plasma samples withdrawn and assayed for ACTH, corticosterone, and GH.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 08AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement

    In rats, AVP did not affect the GH response to GHRP‑6.

    In plain wordsIn rats, AVP did not change the growth hormone response to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    No significant changeAVP effect on GHRP-6-induced GH response
    Study

    ratn: not reported in source

    Conscious rats
    Comparator
    GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Neither CRH nor AVP had any effect on the GH response to GHRP-6.
    2 context sentences
    Summary · context
    We have now examined the activation of the hypothalamo-pituitary-adrenal axis by GHRP-6 in conscious rats.
    Summary · context
    In a series of experiments, rats were injected i.v. with 10 microg GHRP-6, 2 microg CRH, 0.5 microg AVP, or saline, alone or in combination, and serial plasma samples withdrawn and assayed for ACTH, corticosterone, and GH.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

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