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Study · Animal study (in vivo) · rat · 1997

5 results

Hyperalgesia induced by low doses of thymulin injections: possible involvement of prostaglandin E2.

Safieh-Garabedian B, Kanaan SA, Jalakhian RH, Poole S, Jabbur SJ, Saadé NE

Journal of neuroimmunology1 Mar 1997Cited by 12 (Europe PMC)

PMID9058772 (opens in a new tab)DOI10.1016/s0165-5728(96)00195-6 (opens in a new tab)PepBankPUB-09058772
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rats, thymulin significantly reduced the mechanical nociceptive threshold in the paw pressure test.

    In plain wordsIn rats, thymulin lowered the pressure needed to cause pain.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseMechanical nociceptive threshold
    Study

    ratn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    20-150 ng · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Thymulin injection into rats (20-150 ng) i.p. caused a significant reduction in both mechanical (paw pressure test) and thermal (hot plate and tail flick tests) nociceptive thresholds.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In rats, thymulin significantly reduced thermal nociceptive thresholds in hot plate and tail flick tests.

    In plain wordsIn rats, thymulin lowered the heat needed to cause pain.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseThermal nociceptive threshold
    Study

    ratn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    20-150 ng · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Thymulin injection into rats (20-150 ng) i.p. caused a significant reduction in both mechanical (paw pressure test) and thermal (hot plate and tail flick tests) nociceptive thresholds.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, thymulin injection doubled liver IL-1beta levels.

    In plain wordsIn rats, thymulin injections doubled liver levels of the inflammation marker IL-1beta.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseLiver IL-1beta
    Study

    ratn: not reported in source

    rats
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    20-150 ng · intraperitonealAs given in this study (rat).

    Measurements

    IL-1beta level
    2 fold
    liver after thymulin injection

    Source sentences

    Summary
    Thymulin injection also doubled IL-1beta level in the liver of these animals.
    1 context sentence
    Summary · context
    Thymulin injection into rats (20-150 ng) i.p. caused a significant reduction in both mechanical (paw pressure test) and thermal (hot plate and tail flick tests) nociceptive thresholds.

Studies that did not test the peptide alone2

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, low-dose Lys-D-Pro-Val completely reversed thymulin-induced hyperalgesia.

    In plain wordsIn rats, low-dose Lys-D-Pro-Val completely reversed increased pain sensitivity induced by thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseHyperalgesia reversal with Lys-D-Pro-Val
    Study

    ratn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses,

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 05AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, high-dose Lys-D-Pro-Thr only partly reversed thymulin-induced hyperalgesia.

    In plain wordsIn rats, high-dose Lys-D-Pro-Thr only partly reversed increased pain sensitivity induced by thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseHyperalgesia reversal with Lys-D-Pro-Thr
    Study

    ratn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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