Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women.

Butterfield GE, Thompson J, Rennie MJ, Marcus R, Hintz RL, Hoffman AR

The American journal of physiology1 Jan 1997Cited by 65 (Europe PMC)

PMID9038857DOI10.1152/ajpendo.1997.272.1.e94PepBankPUB-09038857

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study20

20 results from studies that gave the peptide. 20 results from people.

01HumanRandomized controlled trialEfficacy outcome
In elderly women, nitrogen balance increased after one week with low-dose rhIGF-I, as in all treatment groups.
In plain wordsIn elderly women, nitrogen balance increased with low-dose rhIGF-I after one week, as in all treatment groups.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseNitrogen balance after one week
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.015 mg/kg twice daily · 1 wkAs given in this study (human).
Measurements
P value for nitrogen balance increase from baseline
< 0.05 unitless
low-dose rhIGF-I, after 1 wk, versus baseline
Source sentences
Summary
Nitrogen balance increased significantly after 1 wk of treatment in all groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885701
02HumanRandomized controlled trialEfficacy outcome
In elderly women, nitrogen balance increased after one week with mid-dose rhIGF-I, as in all treatment groups.
In plain wordsIn elderly women, nitrogen balance increased with mid-dose rhIGF-I after one week, as in all treatment groups.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseNitrogen balance after one week
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.03 mg/kg twice daily · 1 wkAs given in this study (human).
Measurements
P value for nitrogen balance increase from baseline
< 0.05 unitless
mid-dose rhIGF-I, after 1 wk, versus baseline
Source sentences
Summary
Nitrogen balance increased significantly after 1 wk of treatment in all groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885702
03HumanRandomized controlled trialEfficacy outcome
In elderly women, nitrogen balance increased after one week with high-dose rhIGF-I, as in all treatment groups.
In plain wordsIn elderly women, nitrogen balance increased with high-dose rhIGF-I after one week, as in all treatment groups.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseNitrogen balance after one week
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.06 mg/kg twice daily · 1 wkAs given in this study (human).
Measurements
P value for nitrogen balance increase from baseline
< 0.05 unitless
high-dose rhIGF-I, after 1 wk, versus baseline
Source sentences
Summary
Nitrogen balance increased significantly after 1 wk of treatment in all groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885703
04HumanRandomized controlled trialEfficacy outcome
In elderly women, nitrogen balance remained elevated throughout low-dose rhIGF-I treatment.
In plain wordsIn elderly women, nitrogen balance remained above baseline during low-dose rhIGF-I treatment.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseSustained nitrogen balance
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.015 mg/kg twice daily · 1 moAs given in this study (human).
Source sentences
Summary
After 1 mo, the magnitude of this effect had diminished by 50% in the rhGH group but remained elevated throughout the treatment period with all doses of rhIGF-I.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885704
05HumanRandomized controlled trialEfficacy outcome
In elderly women, nitrogen balance remained elevated throughout mid-dose rhIGF-I treatment.
In plain wordsIn elderly women, nitrogen balance remained above baseline during mid-dose rhIGF-I treatment.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseSustained nitrogen balance
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.03 mg/kg twice daily · 1 moAs given in this study (human).
Source sentences
Summary
After 1 mo, the magnitude of this effect had diminished by 50% in the rhGH group but remained elevated throughout the treatment period with all doses of rhIGF-I.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885705
06HumanRandomized controlled trialEfficacy outcome
In elderly women, nitrogen balance remained elevated throughout high-dose rhIGF-I treatment.
In plain wordsIn elderly women, nitrogen balance remained above baseline during high-dose rhIGF-I treatment.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseSustained nitrogen balance
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.06 mg/kg twice daily · 1 moAs given in this study (human).
Source sentences
Summary
After 1 mo, the magnitude of this effect had diminished by 50% in the rhGH group but remained elevated throughout the treatment period with all doses of rhIGF-I.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885706
07HumanRandomized controlled trialEfficacy outcome
In elderly women, low-dose rhIGF-I increased whole-body protein synthesis by 4.5% from baseline.
In plain wordsIn elderly women, low-dose rhIGF-I increased whole-body protein production by 4.5% from baseline.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseWhole-body protein synthesis
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.015 mg/kg twice daily · 1 moAs given in this study (human).
Measurements
Whole-body protein synthesis increase
4.5%
low-dose rhIGF-I 0.015 mg/kg twice daily
Source sentences
Summary
Both protein synthesis and breakdown, measured by a primed constant infusion of [15N]glycine, were significantly increased with rhGH (9% and 8%, respectively), low-dose rhIGF-I (4.5% and 4%), and high-dose rhIGF-I (18% and 17%).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885707
08HumanRandomized controlled trialEfficacy outcome
In elderly women, low-dose rhIGF-I increased whole-body protein breakdown by 4% from baseline.
In plain wordsIn elderly women, low-dose rhIGF-I increased whole-body protein breakdown by 4% from baseline.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseWhole-body protein breakdown
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.015 mg/kg twice daily · 1 moAs given in this study (human).
Measurements
Whole-body protein breakdown increase
4%
low-dose rhIGF-I 0.015 mg/kg twice daily
Source sentences
Summary
Both protein synthesis and breakdown, measured by a primed constant infusion of [15N]glycine, were significantly increased with rhGH (9% and 8%, respectively), low-dose rhIGF-I (4.5% and 4%), and high-dose rhIGF-I (18% and 17%).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885708
09HumanRandomized controlled trialEfficacy outcome
In elderly women, high-dose rhIGF-I increased whole-body protein synthesis by 18% from baseline.
In plain wordsIn elderly women, high-dose rhIGF-I increased whole-body protein production by 18% from baseline.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseWhole-body protein synthesis
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.06 mg/kg twice daily · 1 moAs given in this study (human).
Measurements
Whole-body protein synthesis increase
18%
high-dose rhIGF-I 0.06 mg/kg twice daily
Source sentences
Summary
Both protein synthesis and breakdown, measured by a primed constant infusion of [15N]glycine, were significantly increased with rhGH (9% and 8%, respectively), low-dose rhIGF-I (4.5% and 4%), and high-dose rhIGF-I (18% and 17%).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885709
10HumanRandomized controlled trialEfficacy outcome
In elderly women, high-dose rhIGF-I increased whole-body protein breakdown by 17% from baseline.
In plain wordsIn elderly women, high-dose rhIGF-I increased whole-body protein breakdown by 17% from baseline.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseWhole-body protein breakdown
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.06 mg/kg twice daily · 1 moAs given in this study (human).
Measurements
Whole-body protein breakdown increase
17%
high-dose rhIGF-I 0.06 mg/kg twice daily
Source sentences
Summary
Both protein synthesis and breakdown, measured by a primed constant infusion of [15N]glycine, were significantly increased with rhGH (9% and 8%, respectively), low-dose rhIGF-I (4.5% and 4%), and high-dose rhIGF-I (18% and 17%).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885710
11HumanRandomized controlled trialEfficacy outcome
In elderly women, high-dose rhIGF-I increased net protein synthesis by 27% from baseline.
In plain wordsIn elderly women, high-dose rhIGF-I increased net protein production by 27% from baseline.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseNet protein synthesis
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.06 mg/kg twice daily · 1 moAs given in this study (human).
Measurements
Net protein synthesis increase
27%
high-dose rhIGF-I 0.06 mg/kg twice daily
Source sentences
Summary
Net synthesis was significantly increased with rhGH (48%) and high- and mid-dose rhIGF-I (27% and 196%, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885711
12HumanRandomized controlled trialEfficacy outcome
In elderly women, mid-dose rhIGF-I increased net protein synthesis by 196% from baseline.
In plain wordsIn elderly women, mid-dose rhIGF-I increased net protein production by 196% from baseline.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseNet protein synthesis
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.03 mg/kg twice daily · 1 moAs given in this study (human).
Measurements
Net protein synthesis increase
196%
mid-dose rhIGF-I 0.03 mg/kg twice daily
Source sentences
Summary
Net synthesis was significantly increased with rhGH (48%) and high- and mid-dose rhIGF-I (27% and 196%, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885712
13HumanRandomized controlled trialEfficacy outcome
In elderly women, mid-dose rhIGF-I increased muscle protein synthesis by 67% from baseline.
In plain wordsIn elderly women, mid-dose rhIGF-I increased muscle protein production by 67% from baseline.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseMuscle protein synthesis
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.03 mg/kg twice daily · 1 moAs given in this study (human).
Measurements
Muscle protein synthesis increase
67%
mid-dose rhIGF-I 0.03 mg/kg twice daily
Source sentences
Summary
Muscle protein synthesis as measured by incorporation of [1-13C]leucine increased significantly with rhGH (50%) and the mid (67%) and high (57%) doses of rhIGF-I.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885713
14HumanRandomized controlled trialEfficacy outcome
In elderly women, high-dose rhIGF-I increased muscle protein synthesis by 57% from baseline.
In plain wordsIn elderly women, high-dose rhIGF-I increased muscle protein production by 57% from baseline.
Peptide
IGF-1 (mecasermin)
Outcome
IncreaseMuscle protein synthesis
Study
n: not reported in source
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.06 mg/kg twice daily · 1 moAs given in this study (human).
Measurements
Muscle protein synthesis increase
57%
high-dose rhIGF-I 0.06 mg/kg twice daily
Source sentences
Summary
Muscle protein synthesis as measured by incorporation of [1-13C]leucine increased significantly with rhGH (50%) and the mid (67%) and high (57%) doses of rhIGF-I.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885714
15HumanNon-randomized trialEfficacy outcome
In elderly women, rhGH significantly increased nitrogen balance after 1 week versus before treatment, as did every treatment group.
In plain wordsIn elderly women, rhGH increased nitrogen balance after 1 week versus before treatment, as did every treatment group.
Peptide
HGH (somatotropin)
Outcome
IncreaseNitrogen balance after 1 week
Study
n: not reported in source
Comparator
Before treatment
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.025 mg/kg once daily · 1 weekAs given in this study (human).
Source sentences
Summary
Nitrogen balance increased significantly after 1 wk of treatment in all groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885715
16HumanNon-randomized trialEfficacy outcome
In elderly women, the rhGH nitrogen balance response diminished by 50% after 1 month compared with the initial response.
In plain wordsIn elderly women, the nitrogen balance response to rhGH decreased by 50% after 1 month compared with the initial response.
Peptide
HGH (somatotropin)
Outcome
DecreaseAttenuation of nitrogen balance response
Study
n: not reported in source
Comparator
Response after 1 week
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.025 mg/kg once daily · 1 monthAs given in this study (human).
Measurements
Diminution of nitrogen balance effect
50%
rhGH after 1 month
Source sentences
Summary
After 1 mo, the magnitude of this effect had diminished by 50% in the rhGH group but remained elevated throughout the treatment period with all doses of rhIGF-I.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885716
17HumanNon-randomized trialEfficacy outcome
In elderly women, rhGH significantly increased whole body protein synthesis by 9% versus before treatment.
In plain wordsIn elderly women, rhGH increased whole body protein production by 9% versus before treatment.
Peptide
HGH (somatotropin)
Outcome
IncreaseWhole body protein synthesis
Study
n: not reported in source
Comparator
Before treatment
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.025 mg/kg once daily · 1 monthAs given in this study (human).
Measurements
Protein synthesis increase
9%
rhGH
Source sentences
Summary
Both protein synthesis and breakdown, measured by a primed constant infusion of [15N]glycine, were significantly increased with rhGH (9% and 8%, respectively), low-dose rhIGF-I (4.5% and 4%), and high-dose rhIGF-I (18% and 17%).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885717
18HumanNon-randomized trialEfficacy outcome
In elderly women, rhGH significantly increased whole body protein breakdown by 8% versus before treatment.
In plain wordsIn elderly women, rhGH increased whole body protein breakdown by 8% versus before treatment.
Peptide
HGH (somatotropin)
Outcome
IncreaseWhole body protein breakdown
Study
n: not reported in source
Comparator
Before treatment
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.025 mg/kg once daily · 1 monthAs given in this study (human).
Measurements
Protein breakdown increase
8%
rhGH
Source sentences
Summary
Both protein synthesis and breakdown, measured by a primed constant infusion of [15N]glycine, were significantly increased with rhGH (9% and 8%, respectively), low-dose rhIGF-I (4.5% and 4%), and high-dose rhIGF-I (18% and 17%).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885718
19HumanNon-randomized trialEfficacy outcome
In elderly women, rhGH significantly increased net protein synthesis by 48% versus before treatment.
In plain wordsIn elderly women, rhGH increased net protein production by 48% versus before treatment.
Peptide
HGH (somatotropin)
Outcome
IncreaseNet protein synthesis
Study
n: not reported in source
Comparator
Before treatment
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.025 mg/kg once daily · 1 monthAs given in this study (human).
Measurements
Net synthesis increase
48%
rhGH
Source sentences
Summary
Net synthesis was significantly increased with rhGH (48%) and high- and mid-dose rhIGF-I (27% and 196%, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
Report a problemFND-0903885719
20HumanNon-randomized trialEfficacy outcome
In elderly women, rhGH significantly increased muscle protein synthesis by 50% versus before treatment.
In plain wordsIn elderly women, rhGH increased muscle protein production by 50% versus before treatment.
Peptide
HGH (somatotropin)
Outcome
IncreaseMuscle protein synthesis
Study
n: not reported in source
Comparator
Before treatment
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.025 mg/kg once daily · 1 monthAs given in this study (human).
Measurements
Muscle protein synthesis increase
50%
rhGH
Source sentences
Summary
Muscle protein synthesis as measured by incorporation of [1-13C]leucine increased significantly with rhGH (50%) and the mid (67%) and high (57%) doses of rhIGF-I.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effect of recombinant human growth hormone (rhGH) and recombinant human insulin-like growth factor I (rhIGF-I) on protein utilization, 14 women, age 66-82 yr, were invited to participate in studies of nitrogen balance (n = 14), whole body protein turnover (n = 14), and muscle protein synthesis (n = 8).
Summary · context
They were studied both 1 wk before and during the last week of a 1-mo regimen, to which they had been randomly assigned, of either 0.025 mg rhGH/kg once daily or rhIGF-I at 0.015 (low), 0.03 (mid), or 0.06 (high) mg/kg twice daily.
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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:37 UTC
Study data updated · source update from Europe PMC
Version 2
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women.

Summary

Results from this study20

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