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Study · Animal study (in vivo) · rat · 1997

4 results

Comparison of the ability of recombinant human parathyroid hormone, rhPTH-(1-84), and hPTH-(1-31)NH2 to stimulate femoral trabecular bone growth in ovariectomized rats.

Whitfield JF, Morley P, Willick GE, Ross V, MacLean S, Barbier JR, Isaacs RJ, Ohannessian-Barry L

Calcified tissue international1 Jan 1997Cited by 11 (Europe PMC)

PMID9030476 (opens in a new tab)DOI10.1007/s002239900181 (opens in a new tab)PepBankPUB-09030476
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In young ovariectomized rats, rhPTH-(1-84) reduced femoral trabecular bone loss when treatment started 2 weeks after ovariectomy.

    In plain wordsIn young rats with ovaries removed, rhPTH-(1-84) reduced thigh bone loss.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    DecreaseFemoral trabecular bone loss
    Study

    ratn: not reported in source

    ovariectomized rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.6 nmol/100 g body weight daily · subcutaneous injection · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    Thus daily subcutaneous injections of 0.6 nmol/100 g of body weight of rhPTH-(1-84) or hPTH-(1-31)NH2 into 3-month-old OVX rats for 6 weeks starting 2 weeks after OVX equally reduced the otherwise large OVX-triggered loss of femoral trabecular bone.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In young ovariectomized rats, rhPTH-(1-84) reduced femoral trabecular bone loss equally to hPTH-(1-31)NH2.

    In plain wordsIn rats with ovaries removed, rhPTH-(1-84) reduced thigh bone loss equally to hPTH-(1-31)NH2.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeBone loss reduction versus fragment
    Study

    ratn: not reported in source

    ovariectomized rats
    Comparator
    hPTH-(1-31)NH2
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.6 nmol/100 g body weight daily · subcutaneous injection · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    Thus daily subcutaneous injections of 0.6 nmol/100 g of body weight of rhPTH-(1-84) or hPTH-(1-31)NH2 into 3-month-old OVX rats for 6 weeks starting 2 weeks after OVX equally reduced the otherwise large OVX-triggered loss of femoral trabecular bone.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In young and older ovariectomized rats, rhPTH-(1-84) increased mean femoral trabecular thickness to 20 to 80% above normal animals.

    In plain wordsIn rats with ovaries removed, rhPTH-(1-84) increased thigh bone strut thickness to 20 to 80% above normal animals.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseFemoral trabecular thickness
    Study

    ratn: not reported in source

    ovariectomized rats
    Comparator
    normal animals
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.4 or 0.8 nmol/100 g body weight daily · subcutaneous injection · 6 weeksAs given in this study (rat).

    Measurements

    Trabecular thickness elevation
    20 to 80%
    above normal animals

    Source sentences

    Summary
    4 or 0.8 nmol/100 g of body weight of the two agents for 6 weeks also equally increased the mean thickness of the remaining femoral trabeculae in 3-month-old and 1-year-old OVX rats to 20 to 80% above the value in normal animals when started 9 weeks after ovariectomy.
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 0.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In young and older ovariectomized rats, rhPTH-(1-84) and hPTH-(1-31)NH2 increased mean femoral trabecular thickness equally.

    In plain wordsIn rats with ovaries removed, rhPTH-(1-84) increased thigh bone strut thickness equally to hPTH-(1-31)NH2.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeTrabecular thickness response versus fragment
    Study

    ratn: not reported in source

    ovariectomized rats
    Comparator
    hPTH-(1-31)NH2
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.4 or 0.8 nmol/100 g body weight daily · subcutaneous injection · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    4 or 0.8 nmol/100 g of body weight of the two agents for 6 weeks also equally increased the mean thickness of the remaining femoral trabeculae in 3-month-old and 1-year-old OVX rats to 20 to 80% above the value in normal animals when started 9 weeks after ovariectomy.
    1 context sentence
    Summary · context
    Daily subcutaneous injections of 0.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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