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Study · Animal study (in vivo) · rat · 1997

9 results

Growth hormone release induced by growth hormone-releasing hexapeptide is not mediated by thyrotropin-releasing hormone in neonatal rats.

Kacsóh B, Kacsóh G, Guzzardo MB, Black AC Jr, Bisat T

Pediatric research1 Feb 1997Cited by 2 (Europe PMC)

PMID9029647 (opens in a new tab)DOI10.1203/00006450-199702000-00016 (opens in a new tab)PepBankPUB-09029647
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In neonatal rats, GHRP‑6 induced a greater GH response than TRH.

    In plain wordsIn newborn rats, GHRP‑6 produced a greater growth hormone response than TRH.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response versus TRH in vivo
    Study

    ratn: not reported in source

    Neonatal rats
    Comparator
    TRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 in vivo induced a greater GH response than did TRH.
    1 context sentence
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In neonatal rats, GHRP‑6 was not an effective stimulus of prolactin secretion.

    In plain wordsIn newborn rats, GHRP‑6 did not effectively stimulate prolactin release.

    Peptide
    GHRP-6
    Outcome
    No significant changeProlactin secretion in vivo
    Study

    ratn: not reported in source

    Neonatal rats
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Unlike GHRP-6 TRH was an effective stimulus of prolactin secretion either in vitro or in vivo.
    1 context sentence
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.
  3. 03LabEx vivo tissueActivity measurement

    In neonatal rat pituitary glands, GHRP‑6 stimulated GH secretion.

    In plain wordsIn lab tests with newborn rat pituitary glands, GHRP‑6 increased growth hormone release.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH secretion in vitro
    Study

    ratn: not reported in source

    Neonatal rat pituitary glands
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 and TRH stimulated GH secretion of neonatal pituitary glands.
    1 context sentence
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.
  4. 04LabEx vivo tissueActivity measurement

    In neonatal rat pituitary glands, maximal GHRP‑6 and TRH doses evoked approximately equal GH responses.

    In plain wordsIn lab tests with newborn rat glands, maximal GHRP‑6 and TRH doses produced approximately equal growth hormone responses.

    Peptide
    GHRP-6
    Outcome
    No significant changeMaximal GH response versus TRH
    Study

    ratn: not reported in source

    Neonatal rat pituitary glands
    Comparator
    TRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At their maximally effective doses, GHRP-6 and TRH evoked approximately equal GH responses.
    1 context sentence
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.
  5. 05LabEx vivo tissueActivity measurement

    In neonatal rat pituitary glands, GHRP‑6 plus TRH produced GH responses comparable to TRH alone at maximal doses.

    In plain wordsIn lab tests with newborn rat glands, GHRP‑6 plus TRH produced growth hormone responses comparable to TRH alone.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH response added to TRH in vitro
    Study

    ratn: not reported in source

    Neonatal rat pituitary glands
    Comparator
    TRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with a combination of the maximally effective doses of GHRP-6 and TRH resulted in a GH response comparable to that evoked by either treatment alone.
    1 context sentence
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.
  6. 06LabEx vivo tissueActivity measurement

    In neonatal rat pituitary glands, GHRP‑6 was not an effective stimulus of prolactin secretion.

    In plain wordsIn lab tests with newborn rat glands, GHRP‑6 did not effectively stimulate prolactin release.

    Peptide
    GHRP-6
    Outcome
    No significant changeProlactin secretion in vitro
    Study

    ratn: not reported in source

    Neonatal rat pituitary glands
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Unlike GHRP-6 TRH was an effective stimulus of prolactin secretion either in vitro or in vivo.
    1 context sentence
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 07AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement

    In neonatal rats, GHRP‑6 plus TRH synergistically increased serum GH at maximally effective doses.

    In plain wordsIn newborn rats, GHRP‑6 plus TRH produced a synergistic increase in blood growth hormone.

    Peptide
    GHRP-6
    Outcome
    IncreaseSynergistic GH response with TRH in vivo
    Study

    ratn: not reported in source

    Neonatal rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Treatment in vivo with a combination of the maximally effective doses of GHRP-6 and TRH synergistically increased serum GH levels.
    1 context sentence
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 08AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement

    In neonatal rats, GHRP‑6 and nursing had additive effects on GH secretion.

    In plain wordsIn newborn rats, GHRP‑6 and nursing produced additive growth hormone release.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response with nursing
    Study

    ratn: not reported in source

    Neonatal rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The effects of either of the peptides and nursing on GH secretion were additive.
    2 context sentences
    Summary · context
    GH-releasing hexapeptide (GHRP-6) and nursing stimulate GH secretion in rat pups via GH-releasing factors (GRFs: distinct from GH-releasing hormone (GHRH).
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 09LabNot a test of GHRP-6 aloneEx vivo tissueActivity measurement

    In neonatal rat pituitary glands, GHRP‑6 plus TRH produced GH responses comparable to GHRP‑6 alone at maximal doses.

    In plain wordsIn lab tests with newborn rat glands, GHRP‑6 plus TRH produced growth hormone responses comparable to GHRP‑6 alone.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH response with TRH versus GHRP-6 alone
    Study

    ratn: not reported in source

    Neonatal rat pituitary glands
    Comparator
    GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Treatment with a combination of the maximally effective doses of GHRP-6 and TRH resulted in a GH response comparable to that evoked by either treatment alone.
    1 context sentence
    Summary · context
    It was determined whether GH secretion induced by GHRP-6 or nursing was mediated by TSH-releasing hormone (TRH) in 2-d-old rats.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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