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Study · In vitro (cells) · 1996

4 results

[The effect of thymogen on the chromosome aberration level in a culture of human peripheral blood lymphocytes].

Rushkovskiĭ SR, Chegrinets SE, Bezrukov VF, Khrapunov SN

TSitologiia i genetika1 Sept 1996Cited by 1 (Europe PMC)

PMID9026996 (opens in a new tab)PepBankPUB-09026996
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human lymphocyte cultures, high thymogene concentrations significantly decreased proliferative activity.

    In plain wordsIn cells, high thymogene concentrations significantly reduced human lymphocyte proliferation.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseLymphocyte proliferative activity
    Study

    humann: not reported in source

    peripheral blood lymphocyte culture
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1000, 100, and 10 micrograms/mlAs given in this study (human).

    Source sentences

    Summary
    High thymogene concentration (1000, 100, and 10 micrograms/ml) significantly decreased the proliferative activity of lymphocytes in culture.
    1 context sentence
    Summary · context
    The influence of thymogene on the frequency of spontaneous and formaldehyde-induced chromosome aberrations in human peripheral blood lymphocytes was detected.
  2. 02LabIn vitro (cells)Activity measurement

    In human lymphocyte cultures, low thymogene concentrations did not decrease mitotic activity.

    In plain wordsIn cells, low thymogene concentrations did not reduce human lymphocyte division.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeMitotic activity
    Study

    humann: not reported in source

    peripheral blood lymphocyte culture
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1.0; 0.1; 0.01; and 0.001 microgram/mlAs given in this study (human).

    Source sentences

    Summary
    Low thymogene concentrations (1.0; 0.1; 0.01; and 0.001 microgram/ml) didn't decrease the mitotic activity of culture and hadn't mutagenic activity.
    1 context sentence
    Summary · context
    The influence of thymogene on the frequency of spontaneous and formaldehyde-induced chromosome aberrations in human peripheral blood lymphocytes was detected.
  3. 03LabIn vitro (cells)Safety outcome

    In human lymphocyte cultures, low thymogene concentrations showed no mutagenic activity.

    In plain wordsIn cells, low thymogene concentrations showed no mutation-causing activity.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeMutagenic activity
    Study

    humann: not reported in source

    peripheral blood lymphocyte culture
    Outcome group
    Adverse events · Whole body
    Studied dose
    1.0; 0.1; 0.01; and 0.001 microgram/mlAs given in this study (human).

    Source sentences

    Summary
    Low thymogene concentrations (1.0; 0.1; 0.01; and 0.001 microgram/ml) didn't decrease the mitotic activity of culture and hadn't mutagenic activity.
    1 context sentence
    Summary · context
    The influence of thymogene on the frequency of spontaneous and formaldehyde-induced chromosome aberrations in human peripheral blood lymphocytes was detected.
  4. 04LabIn vitro (cells)Efficacy outcome

    In human lymphocyte cultures, thymogene significantly decreased formaldehyde-induced chromosome aberrations.

    In plain wordsIn cells, thymogene significantly reduced chromosome abnormalities induced by formaldehyde.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseFormaldehyde-induced chromosome aberrations
    Study

    humann: not reported in source

    peripheral blood lymphocyte culture
    Outcome group
    Genome stability · Whole body
    Studied dose
    1.0; 0.1; and 0.001 microgram/mlAs given in this study (human).

    Source sentences

    Summary
    Thymogene concentrations 1.0; 0.1; and 0.001 microgram/ml significantly decreased the frequency of formaldehyde-induced chromosome aberrations in lymphocytes.
    1 context sentence
    Summary · context
    The influence of thymogene on the frequency of spontaneous and formaldehyde-induced chromosome aberrations in human peripheral blood lymphocytes was detected.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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