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Study · In vitro (cells) · 1996

3 results

Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells?

Cianfarani S, Germani D, Rossi P, Spagnoli A, Mercanti D

European journal of endocrinology1 Dec 1996Cited by 6 (Europe PMC)

PMID9025718 (opens in a new tab)DOI10.1530/eje.0.1350716 (opens in a new tab)PepBankPUB-09025718
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In SH-SY5Y cells, des(1‑3)IGF-I maximally stimulated cell proliferation.

    In plain wordsIn cells, des(1‑3)IGF-I maximally stimulated cell growth.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseCell proliferation
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The SH-SY5Y cell proliferation was maximally stimulated by des(1-3)IGF-I.
  2. 02LabIn vitro (cells)Mechanism

    In SH-SY5Y cells, des(1‑3)IGF-I potentiated TPA-induced differentiation assessed by cell morphology.

    In plain wordsIn cells, des(1‑3)IGF-I increased differentiation assessed by cell shape compared with TPA alone.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseDifferentiation assessed by cell morphology
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells
    Comparator
    TPA alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The TPA-induced differentiation of SH-SY5Y, evaluated by assessment of cell morphology and GAP-43 expression as a biochemical marker of differentiation was potentiated by nanomolar concentrations of des(1-3)IGF-I and, to a smaller extent, IGF-I
  3. 03LabIn vitro (cells)Mechanism

    In SH-SY5Y cells, des(1‑3)IGF-I potentiated TPA-induced differentiation assessed by GAP-43 expression.

    In plain wordsIn cells, des(1‑3)IGF-I increased differentiation assessed by GAP-43 expression compared with TPA alone.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseDifferentiation assessed by GAP-43 expression
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells
    Comparator
    TPA alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The TPA-induced differentiation of SH-SY5Y, evaluated by assessment of cell morphology and GAP-43 expression as a biochemical marker of differentiation was potentiated by nanomolar concentrations of des(1-3)IGF-I and, to a smaller extent, IGF-I

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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