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Study · Not a test of the peptide alone · 1996

2 results

Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists.

Haskell-Luevano C, Sawyer TK, Trumpp-Kallmeyer S, Bikker JA, Humblet C, Gantz I, Hruby VJ

Drug design and discovery1 Dec 1996Cited by 46 (Europe PMC)

PMID9017363 (opens in a new tab)PepBankPUB-09017363
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 01Computer modelNot a test of Melanotan II aloneIn silicoMechanism

    In molecular models of human MC1R, the melanotropin side chains DPhe7 and Trp9 are proposed to interact with a hydrophobic network of aromatic receptor residues.

    In plain wordsIn computer models, parts of melanotropin peptides are predicted to contact water-repelling parts of the MC1 receptor.

    Peptide
    Melanotan II
    Outcome
    Not applicableProposed hydrophobic ligand-receptor interactions
    Study

    n: not reported in source

    Three-dimensional molecular models of human MC1R
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The melanotropin sidechain pharmacophores, DPhe7 and Trp9, are proposed to interact with a hydrophobic network of receptor aromatic residues in transmembrane regions 4, 5, 6, and 7.
    1 context sentence
    Title · context
    Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 02Computer modelNot a test of Melanotan II aloneIn silicoMechanism

    In molecular models of human MC1R, a hydrophilic network involving ligand Arg8 and polar receptor residues in transmembrane regions 2 and 3 was identified.

    In plain wordsIn computer models, an arginine in melanotropin peptides is predicted to contact polar parts of the MC1 receptor.

    Peptide
    Melanotan II
    Outcome
    Not applicableProposed hydrophilic ligand-receptor interactions
    Study

    n: not reported in source

    Three-dimensional molecular models of human MC1R
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In addition, a hydrophilic network involving the ligand Arg8 and polar receptor residues located in transmembrane regions 2 and 3 were identified.
    1 context sentence
    Title · context
    Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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