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Study · Non-randomized trial · n = 26 · 1996

11 results

Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome.

Louvel D, Delvaux M, Felez A, Fioramonti J, Bueno L, Lazorthes Y, Frexinos J

Gut1 Nov 1996Cited by 87 (Europe PMC)

PMID9014776 (opens in a new tab)PMCIDPMC1383401 (opens in a new tab)DOI10.1136/gut.39.5.741 (opens in a new tab)PepBankPUB-09014776
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin 10 mU/min did not significantly change the colonic distension pressure needed for a first abdominal sensation versus placebo.

    In plain wordsIn people with irritable bowel syndrome, oxytocin at the lowest dose did not change when they first felt colonic distension, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeDistension pressure for first abdominal sensation
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    10 mU/min · continuous infusionAs given in this study (human).

    Measurements

    Distension pressure, first sensation
    19.9 mm Hg
    oxytocin 10 mU/min
    Distension pressure, first sensation
    17.3 mm Hg
    placebo

    Source sentences

    Summary
    The distension pressure (mean (SD)) required to induce a first abdominal sensation was 17.3 (5.5) mm Hg on placebo, 19.9 (5.8) on oxytocin 10 mU/min (NS), 22.3 (6.0) mm Hg on oxytocin 20 mU/min (p < 0.01), 23.1 (6.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 24.0 (7.1) mm Hg on oxytocin 50 mU/min (p < 0.01).
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin 20 mU/min raised the colonic distension pressure needed for a first abdominal sensation versus placebo.

    In plain wordsIn people with irritable bowel syndrome, oxytocin at 20 mU/min raised the pressure needed to first feel colonic distension, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDistension pressure for first abdominal sensation
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    20 mU/min · continuous infusionAs given in this study (human).

    Measurements

    Distension pressure, first sensation
    22.3 mm Hg
    oxytocin 20 mU/min
    Distension pressure, first sensation
    17.3 mm Hg
    placebo

    Source sentences

    Summary
    The distension pressure (mean (SD)) required to induce a first abdominal sensation was 17.3 (5.5) mm Hg on placebo, 19.9 (5.8) on oxytocin 10 mU/min (NS), 22.3 (6.0) mm Hg on oxytocin 20 mU/min (p < 0.01), 23.1 (6.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 24.0 (7.1) mm Hg on oxytocin 50 mU/min (p < 0.01).
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin 30 mU/min raised the colonic distension pressure needed for a first abdominal sensation versus placebo.

    In plain wordsIn people with irritable bowel syndrome, oxytocin at 30 mU/min raised the pressure needed to first feel colonic distension, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDistension pressure for first abdominal sensation
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    30 mU/min · continuous infusionAs given in this study (human).

    Measurements

    Distension pressure, first sensation
    23.1 mm Hg
    oxytocin 30 mU/min
    Distension pressure, first sensation
    17.3 mm Hg
    placebo

    Source sentences

    Summary
    The distension pressure (mean (SD)) required to induce a first abdominal sensation was 17.3 (5.5) mm Hg on placebo, 19.9 (5.8) on oxytocin 10 mU/min (NS), 22.3 (6.0) mm Hg on oxytocin 20 mU/min (p < 0.01), 23.1 (6.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 24.0 (7.1) mm Hg on oxytocin 50 mU/min (p < 0.01).
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  4. 04HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin 50 mU/min raised the colonic distension pressure needed for a first abdominal sensation versus placebo.

    In plain wordsIn people with irritable bowel syndrome, oxytocin at 50 mU/min raised the pressure needed to first feel colonic distension, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDistension pressure for first abdominal sensation
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    50 mU/min · continuous infusionAs given in this study (human).

    Measurements

    Distension pressure, first sensation
    24 mm Hg
    oxytocin 50 mU/min
    Distension pressure, first sensation
    17.3 mm Hg
    placebo

    Source sentences

    Summary
    The distension pressure (mean (SD)) required to induce a first abdominal sensation was 17.3 (5.5) mm Hg on placebo, 19.9 (5.8) on oxytocin 10 mU/min (NS), 22.3 (6.0) mm Hg on oxytocin 20 mU/min (p < 0.01), 23.1 (6.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 24.0 (7.1) mm Hg on oxytocin 50 mU/min (p < 0.01).
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  5. 05HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin 10 mU/min did not significantly change the colonic distension pressure needed to induce pain versus placebo.

    In plain wordsIn people with irritable bowel syndrome, oxytocin at the lowest dose did not change the pressure at which colonic distension became painful, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeDistension pressure for pain
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    10 mU/min · continuous infusionAs given in this study (human).

    Measurements

    Distension pressure, pain
    26 mm Hg
    oxytocin 10 mU/min
    Distension pressure, pain
    24.8 mm Hg
    placebo

    Source sentences

    Summary
    The distension pressure required to induce pain was 24.8 (6.3) mm Hg on placebo, 26.0 (5.8) on oxytocin 10 mU/min (NS), 33.3 (7.8) mm Hg on oxytocin 20 mU/min (p < 0.01), 34.2 (7.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 34.3 (7.9) mm Hg on oxytocin 50 mU/ min (p < 0.01).
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  6. 06HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin 20 mU/min raised the colonic distension pressure needed to induce pain versus placebo.

    In plain wordsIn people with irritable bowel syndrome, oxytocin at 20 mU/min raised the pressure at which colonic distension became painful, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDistension pressure for pain
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    20 mU/min · continuous infusionAs given in this study (human).

    Measurements

    Distension pressure, pain
    33.3 mm Hg
    oxytocin 20 mU/min
    Distension pressure, pain
    24.8 mm Hg
    placebo

    Source sentences

    Summary
    The distension pressure required to induce pain was 24.8 (6.3) mm Hg on placebo, 26.0 (5.8) on oxytocin 10 mU/min (NS), 33.3 (7.8) mm Hg on oxytocin 20 mU/min (p < 0.01), 34.2 (7.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 34.3 (7.9) mm Hg on oxytocin 50 mU/ min (p < 0.01).
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  7. 07HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin 30 mU/min raised the colonic distension pressure needed to induce pain versus placebo.

    In plain wordsIn people with irritable bowel syndrome, oxytocin at 30 mU/min raised the pressure at which colonic distension became painful, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDistension pressure for pain
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    30 mU/min · continuous infusionAs given in this study (human).

    Measurements

    Distension pressure, pain
    34.2 mm Hg
    oxytocin 30 mU/min
    Distension pressure, pain
    24.8 mm Hg
    placebo

    Source sentences

    Summary
    The distension pressure required to induce pain was 24.8 (6.3) mm Hg on placebo, 26.0 (5.8) on oxytocin 10 mU/min (NS), 33.3 (7.8) mm Hg on oxytocin 20 mU/min (p < 0.01), 34.2 (7.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 34.3 (7.9) mm Hg on oxytocin 50 mU/ min (p < 0.01).
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  8. 08HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin 50 mU/min raised the colonic distension pressure needed to induce pain versus placebo.

    In plain wordsIn people with irritable bowel syndrome, oxytocin at 50 mU/min raised the pressure at which colonic distension became painful, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDistension pressure for pain
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Gastrointestinal
    Studied dose
    50 mU/min · continuous infusionAs given in this study (human).

    Measurements

    Distension pressure, pain
    34.3 mm Hg
    oxytocin 50 mU/min
    Distension pressure, pain
    24.8 mm Hg
    placebo

    Source sentences

    Summary
    The distension pressure required to induce pain was 24.8 (6.3) mm Hg on placebo, 26.0 (5.8) on oxytocin 10 mU/min (NS), 33.3 (7.8) mm Hg on oxytocin 20 mU/min (p < 0.01), 34.2 (7.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 34.3 (7.9) mm Hg on oxytocin 50 mU/ min (p < 0.01).
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  9. 09HumanNon-randomized trialMechanism

    In patients with irritable bowel syndrome, colonic compliance curves did not differ between placebo and oxytocin at the doses tested.

    In plain wordsIn people with irritable bowel syndrome, oxytocin did not change how stretchy the colon was, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeColonic compliance curves
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    10, 20, 30, and 50 mU/min · continuous infusionAs given in this study (human).

    Source sentences

    Summary
    Compliance curves were not different after placebo and oxytocin injection at the different doses.
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  10. 10HumanNon-randomized trialMechanism

    In patients with irritable bowel syndrome, naloxone did not inhibit the effect of oxytocin on visceral perception.

    In plain wordsIn people with irritable bowel syndrome, the opioid blocker naloxone did not stop the effect of oxytocin on colonic sensation.

    Peptide
    Oxytocin
    Outcome
    Not applicableEffect of oxytocin with naloxone
    Study

    n = 26

    Outcome group
    Pain · Gastrointestinal
    Studied dose
    Dose not stated · continuous infusionAs given in this study (human).

    Source sentences

    Summary
    Naloxone did not inhibit the effect of oxytocin.
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…
  11. 11HumanNon-randomized trialEfficacy outcome

    In patients with irritable bowel syndrome, oxytocin did not alter somatic perception, measured by the RIII reflex at the biceps femoris.

    In plain wordsIn people with irritable bowel syndrome, oxytocin did not change pain perception from the leg muscle reflex test, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSomatic perception (RIII reflex)
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10, 20, 30, and 50 mU/min · continuous infusionAs given in this study (human).

    Source sentences

    Summary
    Oxytocin also did not alter somatic perception, characterised by the RIII reflex at the level of the biceps femori.
    2 context sentences
    Summary · context
    The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat.
    Summary · context
    Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various dos…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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