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Study · In vitro (cells) · rat · 1997

2 results

Wortmannin converts insulin but not oxytocin from an antilipolytic to a lipolytic agent in the presence of forskolin.

Fain JN, Gokmen-Polar Y, Bahouth SW

Metabolism: clinical and experimental1 Jan 1997Cited by 2 (Europe PMC)

PMID9005971 (opens in a new tab)DOI10.1016/s0026-0495(97)90169-4 (opens in a new tab)PepBankPUB-09005971
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat adipocytes, the antilipolytic effect of oxytocin was not changed by 500 nmol/L wortmannin, which blocked the antilipolytic action of insulin.

    In plain wordsIn rat fat cells, wortmannin did not block oxytocin's fat-breakdown-reducing effect, but it did block insulin's.

    Peptide
    Oxytocin
    Outcome
    No significant changeAntilipolytic effect of oxytocin with wortmannin
    Study

    ratn: not reported in source

    rat adipocytes
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antilipolytic effects of peroxovanadate and oxytocin were unaffected by 500 nmol/L wortmannin, which blocked the antilipolytic action of insulin.
    1 context sentence
    Summary · context
    The present studies compared the effects of insulin in rat adipocytes with the effects of oxytocin and peroxovanadate, which mimic some effects of insulin.
  2. 02LabIn vitro (cells)Mechanism

    In rat adipocytes, wortmannin had little effect on the stimulation of glucose metabolism by oxytocin.

    In plain wordsIn rat fat cells, wortmannin had little effect on oxytocin's stimulation of glucose use.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin-stimulated glucose metabolism with wortmannin
    Study

    ratn: not reported in source

    rat adipocytes
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while having little effect on that due to oxytocin.
    1 context sentence
    Summary · context
    The present studies compared the effects of insulin in rat adipocytes with the effects of oxytocin and peroxovanadate, which mimic some effects of insulin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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