Effects of growth hormone secretagogues in the transgenic growth-retarded (Tgr) rat.

Wells T, Flavell DM, Wells SE, Carmignac DF, Robinson IC

Endocrinology1 Feb 1997Cited by 23 (Europe PMC)

PMID9002989DOI10.1210/endo.138.2.4917PepBankPUB-09002989

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Tgr rats, pulsatile GHRP‑6 infusions stimulated growth.
In plain wordsIn transgenic growth-retarded rats, pulses of GHRP‑6 stimulated growth.
Peptide
GHRP-6
Outcome
IncreaseGrowth
Study
ratn: not reported in source
Transgenic growth-retarded rats
Outcome group
Linear growth · Endocrine and hormones
Studied dose
Dose not stated · intravenous pulsatile infusionAs given in this study (rat).
Source sentences
Summary
Furthermore, 7-day iv infusions of GRF (12.5-100 micrograms/day), given either continuously or as a pulsatile infusion stimulated growth in Tgr rats, as did pulsatile infusions of GHRP-6.
Report a problemFND-0900298903

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In anesthetized male Tgr rats, GH responses to GHRP‑6 were markedly lower than in nontransgenic littermates.
In plain wordsIn anesthetized male rats, the transgenic growth-retarded group had lower growth hormone responses to GHRP‑6 than normal littermates.
Peptide
GHRP-6
Outcome
DecreaseGH response in anesthetized males
Study
ratn: not reported in source
Transgenic growth-retarded rats
Comparator
Nontransgenic littermates
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In anesthetized male Tgr rats, the GH responses to GRF or GHRP-6 were markedly reduced compared with those of their nontransgenic littermates, but the differences were smaller in females.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0900298901
03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In anesthetized female Tgr rats, reductions in GH responses to GHRP‑6 versus nontransgenic littermates were smaller than in males.
In plain wordsIn female rats, transgenic growth retardation reduced the response to GHRP‑6 less than in males, compared with normal littermates.
Peptide
GHRP-6
Outcome
DecreaseGH response in anesthetized females
Study
ratn: not reported in source
Transgenic growth-retarded rats
Comparator
Nontransgenic littermates
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In anesthetized male Tgr rats, the GH responses to GRF or GHRP-6 were markedly reduced compared with those of their nontransgenic littermates, but the differences were smaller in females.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0900298902

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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