Comparison of inotropic and chronotropic effects of vasoactive intestinal peptide in isolated dog atria.

Wallick DW, Stuesse SL

Journal of the autonomic nervous system1 Dec 1996Cited by 1 (Europe PMC)

PMID8988483DOI10.1016/s0165-1838(96)00091-4PepBankPUB-08988483

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In isolated dog atria, VIP increased contractile force with a mean EC50 of 136 pmol.
In plain wordsIn lab tests on dog heart tissue, VIP increased the force of heart contractions.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseInotropic response EC50
Study
dogn: not reported in source
Isolated canine right atrial preparation
Outcome group
Heart function · Cardiovascular
Studied dose
18.8-600 pmol · injection into sinoatrial nodal arteryAs given in this study (dog).
Measurements
EC50
136 pmol
inotropic response
Source sentences
Summary
The mean EC50 was similar for the inotropic and the chronotropic responses (136 and 144 pmol, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation.
Summary · context
Atria were removed, maintained in a bath, and perfused with Tyrode's solution.
Report a problemFND-0898848301
02LabEx vivo tissueEfficacy outcome
In isolated dog atria, VIP increased atrial rate with a mean EC50 of 144 pmol.
In plain wordsIn lab tests on dog heart tissue, VIP increased the heart rate.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseChronotropic response EC50
Study
dogn: not reported in source
Isolated canine right atrial preparation
Outcome group
Heart function · Cardiovascular
Studied dose
18.8-600 pmol · injection into sinoatrial nodal arteryAs given in this study (dog).
Measurements
EC50
144 pmol
chronotropic response
Source sentences
Summary
The mean EC50 was similar for the inotropic and the chronotropic responses (136 and 144 pmol, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation.
Summary · context
Atria were removed, maintained in a bath, and perfused with Tyrode's solution.
Report a problemFND-0898848302
03LabEx vivo tissueEfficacy outcome
In isolated dog atria, onset times of VIP effects were similar, but the rate of development and the recovery time of the responses were dose dependent.
In plain wordsIn lab tests on dog heart tissue, VIP effects began at similar times, but how fast they grew and faded depended on the dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
MixedOnset and recovery time of VIP responses
Study
dogn: not reported in source
Isolated canine right atrial preparation
Outcome group
Heart function · Cardiovascular
Studied dose
18.8-600 pmol · injection into sinoatrial nodal arteryAs given in this study (dog).
Source sentences
Summary
Times for onset of VIP effects were similar but, once the effect was initiated, rate of development of the response and recovery time from the responses were dose dependent.
2 context sentences(design, population, supporting numbers)
Summary · context
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation.
Summary · context
Atria were removed, maintained in a bath, and perfused with Tyrode's solution.
Report a problemFND-0898848303
04LabEx vivo tissueEfficacy outcome
In isolated dog atria, VIP-induced increases in atrial rate lasted two to four times longer than increases in contractile force.
In plain wordsIn lab tests on dog heart tissue, VIP raised heart rate for two to four times longer than it raised contraction force.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseDuration of rate versus force increases
Study
dogn: not reported in source
Isolated canine right atrial preparation
Outcome group
Heart function · Cardiovascular
Studied dose
18.8-600 pmol · injection into sinoatrial nodal arteryAs given in this study (dog).
Source sentences
Summary
The increases in atrial rate lasted two to four times longer than did the increases in contractile force.
2 context sentences(design, population, supporting numbers)
Summary · context
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation.
Summary · context
Atria were removed, maintained in a bath, and perfused with Tyrode's solution.
Report a problemFND-0898848304
05LabEx vivo tissueEfficacy outcome
In isolated dog atria, isoproterenol was a slightly more potent chronotropic and inotropic agent than VIP.
In plain wordsIn lab tests on dog heart tissue, VIP was slightly less potent than isoproterenol at raising heart rate and contraction force.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreasePotency relative to isoproterenol
Study
dogn: not reported in source
Isolated canine right atrial preparation
Comparator
Isoproterenol
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · injection into sinoatrial nodal arteryAs given in this study (dog).
Source sentences
Summary
Isoproterenol was a slightly more potent chronotropic and inotropic agent than VIP.
2 context sentences(design, population, supporting numbers)
Summary · context
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation.
Summary · context
Atria were removed, maintained in a bath, and perfused with Tyrode's solution.
Report a problemFND-0898848305
06LabEx vivo tissueEfficacy outcome
In isolated dog atria, repeated exposures to VIP decreased the chronotropic response.
In plain wordsIn lab tests on dog heart tissue, repeated VIP doses reduced the heart rate response.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseDesensitization of chronotropic response
Study
dogn: not reported in source
Isolated canine right atrial preparation
Outcome group
Heart function · Cardiovascular
Studied dose
18.8-600 pmol · injection into sinoatrial nodal arteryAs given in this study (dog).
Source sentences
Summary
Repeated exposures to VIP decreased the chronotropic response but not the inotropic response to VIP.
2 context sentences(design, population, supporting numbers)
Summary · context
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation.
Summary · context
Atria were removed, maintained in a bath, and perfused with Tyrode's solution.
Report a problemFND-0898848306
07LabEx vivo tissueEfficacy outcome
In isolated dog atria, repeated exposures to VIP did not decrease the inotropic response.
In plain wordsIn lab tests on dog heart tissue, repeated VIP doses did not reduce the force of contraction response.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeDesensitization of inotropic response
Study
dogn: not reported in source
Isolated canine right atrial preparation
Outcome group
Heart function · Cardiovascular
Studied dose
18.8-600 pmol · injection into sinoatrial nodal arteryAs given in this study (dog).
Source sentences
Summary
Repeated exposures to VIP decreased the chronotropic response but not the inotropic response to VIP.
2 context sentences(design, population, supporting numbers)
Summary · context
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation.
Summary · context
Atria were removed, maintained in a bath, and perfused with Tyrode's solution.
Report a problemFND-0898848307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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