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Study · Animal study (in vivo) · 1996

3 results

[Comparative investigation of anticonvulsive effects of putrescine and structural analogues of delta-sleep-inducing peptide].

Uskova NI, Lysenko AV, Mendzheritskii AM

Vestnik Rossiiskoi akademii meditsinskikh nauk1 Jan 1996

PMID8983406 (opens in a new tab)PepBankPUB-08983406
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals under hyperbaric oxygenation, intraperitoneal delta-sleep-inducing peptide or its analogues ID-1 or ID-3 were less effective than intracysternal putrescine in prolonging the latent period of generalized convulsive activity.

    In plain wordsIn animals, delta sleep-inducing peptide was less effective than putrescine at delaying convulsions under high oxygen pressure.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLatent period of generalized convulsive activity under hyperbaric oxygenation
    Study

    n: not reported in source

    Comparator
    Putrescine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    Intracysternal putrescine before a session of hyperbaric oxygenation (0.7 MPa) was shown to be more effective in prolonging the latent period of onset of generalized convulsive activity than intraperitoneal delta-sleep-inducing peptide or its structural analogues ID-1 or ID-3.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In animals under hyperbaric oxygenation, putrescine was more effective than delta-sleep-inducing peptide and its analogues in preventing the decrease of GABA and homocarnosine in the brain.

    In plain wordsIn animals, putrescine was better than delta sleep-inducing peptide at preventing falls in brain GABA and homocarnosine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseBrain GABA and homocarnosine decrease under hyperbaric oxygenation
    Study

    n: not reported in source

    Comparator
    Putrescine
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    Biochemical studies indicated that putrescine was also more effective in preventing hyperbaric oxygenation-induced decreases in the levels of GABA and homocarnosine in the brain and the accumulation of lipid peroxidation products in the brain and serum.
    1 context sentence
    Summary · context
    Intracysternal putrescine before a session of hyperbaric oxygenation (0.7 MPa) was shown to be more effective in prolonging the latent period of onset of generalized convulsive activity than intraperitoneal delta-sleep-inducing peptide or its structural analogues ID-1 or ID-3.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In animals under hyperbaric oxygenation, putrescine was more effective than delta-sleep-inducing peptide and its analogues in preventing accumulation of lipid peroxidation products in brain and serum.

    In plain wordsIn animals, putrescine was better than delta sleep-inducing peptide at preventing build-up of lipid peroxidation products.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLipid peroxidation products in brain and serum under hyperbaric oxygenation
    Study

    n: not reported in source

    Comparator
    Putrescine
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    Biochemical studies indicated that putrescine was also more effective in preventing hyperbaric oxygenation-induced decreases in the levels of GABA and homocarnosine in the brain and the accumulation of lipid peroxidation products in the brain and serum.
    1 context sentence
    Summary · context
    Intracysternal putrescine before a session of hyperbaric oxygenation (0.7 MPa) was shown to be more effective in prolonging the latent period of onset of generalized convulsive activity than intraperitoneal delta-sleep-inducing peptide or its structural analogues ID-1 or ID-3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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