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Study · In vitro (cells) · 1996

5 results

Brain-derived peptides increase the expression of a blood-brain barrier GLUT1 glucose transporter reporter gene.

Boado RJ

Neuroscience letters1 Dec 1996Cited by 23 (Europe PMC)

PMID8977147 (opens in a new tab)DOI10.1016/s0304-3940(96)13237-7 (opens in a new tab)PepBankPUB-08977147
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In brain endothelial cultured cells, Cerebrolysin markedly increased luciferase expression from a BBB-GLUT1 reporter gene.

    In plain wordsIn cells, Cerebrolysin increased expression from a reporter gene with the BBB-GLUT1 regulatory sequence.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBBB-GLUT1 reporter expression
    Study

    n: not reported in source

    Brain endothelial cultured ECL cells with reporter genes
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Dose response studies showed that C1 markedly increased the expression of luciferase when the BBB-GLUT1-reporter gene was used.
    1 context sentence
    Summary · context
    the present investigation studied the effect of C1 on the expression of a BBB-GLUT1-luciferase reporter gene in brain endothelial cultured (ECL) cells.
  2. 02LabIn vitro (cells)Mechanism

    In brain endothelial cultured cells, Cerebrolysin did not change expression of a control reporter lacking the GLUT1 regulatory sequence.

    In plain wordsIn cells, Cerebrolysin did not change expression from a control reporter without the GLUT1 regulatory sequence.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeControl reporter expression
    Study

    n: not reported in source

    Brain endothelial cultured ECL cells with reporter genes
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the contrary, C1 produced no changes in the expression pattern of the control reporter gene, which lacks the GLUT1 regulatory sequence.
    1 context sentence
    Summary · context
    the present investigation studied the effect of C1 on the expression of a BBB-GLUT1-luciferase reporter gene in brain endothelial cultured (ECL) cells.

Studies that did not test the peptide alone3

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 03LabNot a test of Cerebrolysin aloneIn vitro (cells)Mechanism

    In brain endothelial cultured cells, PKC desensitization with TPA did not alter Cerebrolysin-induced luciferase increases.

    In plain wordsIn cells, TPA treatment did not alter the increase in luciferase induced by Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeTPA effect on induced luciferase
    Study

    n: not reported in source

    Brain endothelial cultured ECL cells with reporter genes
    Comparator
    Cerebrolysin-induced luciferase without PKC desensitization
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Desensitization of the protein kinase C (PKC) receptor with the phorbol ester TPA, or inhibition with either 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) or staurosporine, had no effect on the increased levels of luciferase induced by C1.
    1 context sentence
    Summary · context
    the present investigation studied the effect of C1 on the expression of a BBB-GLUT1-luciferase reporter gene in brain endothelial cultured (ECL) cells.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  2. 04LabNot a test of Cerebrolysin aloneIn vitro (cells)Mechanism

    In brain endothelial cultured cells, PKC inhibition with H7 did not alter Cerebrolysin-induced luciferase increases.

    In plain wordsIn cells, H7 treatment did not alter the increase in luciferase induced by Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeH7 effect on induced luciferase
    Study

    n: not reported in source

    Brain endothelial cultured ECL cells with reporter genes
    Comparator
    Cerebrolysin-induced luciferase without PKC inhibition
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Desensitization of the protein kinase C (PKC) receptor with the phorbol ester TPA, or inhibition with either 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) or staurosporine, had no effect on the increased levels of luciferase induced by C1.
    1 context sentence
    Summary · context
    the present investigation studied the effect of C1 on the expression of a BBB-GLUT1-luciferase reporter gene in brain endothelial cultured (ECL) cells.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  3. 05LabNot a test of Cerebrolysin aloneIn vitro (cells)Mechanism

    In brain endothelial cultured cells, PKC inhibition with staurosporine did not alter Cerebrolysin-induced luciferase increases.

    In plain wordsIn cells, staurosporine treatment did not alter the increase in luciferase induced by Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeStaurosporine effect on induced luciferase
    Study

    n: not reported in source

    Brain endothelial cultured ECL cells with reporter genes
    Comparator
    Cerebrolysin-induced luciferase without PKC inhibition
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Desensitization of the protein kinase C (PKC) receptor with the phorbol ester TPA, or inhibition with either 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) or staurosporine, had no effect on the increased levels of luciferase induced by C1.
    1 context sentence
    Summary · context
    the present investigation studied the effect of C1 on the expression of a BBB-GLUT1-luciferase reporter gene in brain endothelial cultured (ECL) cells.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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