Pituitary enlargement due to primary hypothyroidism: growth hormone response to GHRH, GHRP-6 and GHRH plus GHRP-6.

Damjanović S, Popović V, Petakov M, Djurović M, Dieguez C, Casanueva FF

Journal of pediatric endocrinology & metabolism : JPEM1 Sept 1996Cited by 2 (Europe PMC)

PMID8961133DOI10.1515/jpem.1996.9.5.549PepBankPUB-08961133

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01HumanNot a test of GHRP-6 aloneCase report or seriesMechanism
In a patient with primary hypothyroidism, GHRP‑6-induced GH AUC was higher after thyroid hormone replacement than before.
In plain wordsIn a patient with hypothyroidism, the growth hormone response to GHRP‑6 was higher after thyroid treatment than before treatment.
Peptide
GHRP-6
Outcome
IncreaseGHRP-6-stimulated GH AUC after thyroid replacement
Study
n = 1
Comparator
before thyroid hormone replacement
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC (0-120 min) after GHRP-6
197.2 micrograms/l min
before thyroid hormone replacement
GH AUC (0-120 min) after GHRP-6
650.4 micrograms/l min
after thyroid hormone replacement
Source sentences
Summary
GH secretion induced by GHRP-6 increased after treatment (AUCzero-120 min 197.2 vs 650.4 micrograms/l min).
1 context sentence(design, population, supporting numbers)
Summary · context
GH secretion after growth hormone-releasing hormone (GHRH), growth hormone releasing peptide-6 (GHRP-6) and after combined administration of both peptides was studied in a patient with lactotrope and thyrotrope hyperplasia due to primary hypothyroidism.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0896113301
02HumanNot a test of GHRP-6 aloneCase report or seriesMechanism
In a patient with primary hypothyroidism, delta GH after GHRP‑6 was higher after thyroid hormone replacement than before.
In plain wordsIn a patient with hypothyroidism, the peak growth hormone rise after GHRP‑6 was higher after thyroid treatment than before treatment.
Peptide
GHRP-6
Outcome
IncreaseGHRP-6-stimulated delta GH after thyroid replacement
Study
n = 1
Comparator
before thyroid hormone replacement
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Delta GH after GHRP-6
4 micrograms/l
before thyroid hormone replacement
Delta GH after GHRP-6
18.3 micrograms/l
after thyroid hormone replacement
Source sentences
Summary
GH secretion induced by GHRP-6 increased after treatment (AUCzero-120 min 197.2 vs 650.4 micrograms/l min). delta GH increments were 4.0 and 18.3 micrograms/l before and after therapy respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
GH secretion after growth hormone-releasing hormone (GHRH), growth hormone releasing peptide-6 (GHRP-6) and after combined administration of both peptides was studied in a patient with lactotrope and thyrotrope hyperplasia due to primary hypothyroidism.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0896113302
03HumanNot a test of GHRP-6 aloneCase report or seriesMechanism
In a patient with primary hypothyroidism, combined GHRH and GHRP‑6 produced greater GH AUC after thyroid replacement than before therapy.
In plain wordsIn a patient with hypothyroidism, combined GHRH and GHRP‑6 produced greater growth hormone response after thyroid treatment than before treatment.
Peptide
GHRP-6
Outcome
IncreaseCombined peptide GH AUC after thyroid replacement
Study
n = 1
Comparator
before thyroid hormone replacement
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC (0-120 min) after GHRH plus GHRP-6
1043.2 micrograms/l min
before pituitary pseudotumor resolution
GH AUC (0-120 min) after GHRH plus GHRP-6
2046.7 micrograms/l min
after pituitary pseudotumor resolution
Source sentences
Summary
When the peptides were administered together a synergistic effect on GH secretion was observed but GH release was much more powerful after pituitary pseudotumor disappearance (AUCzero-120 min 1043.2 vs 2046.7 micrograms/l min).
1 context sentence(design, population, supporting numbers)
Summary · context
GH secretion after growth hormone-releasing hormone (GHRH), growth hormone releasing peptide-6 (GHRP-6) and after combined administration of both peptides was studied in a patient with lactotrope and thyrotrope hyperplasia due to primary hypothyroidism.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0896113303
04HumanNot a test of GHRP-6 aloneCase report or seriesMechanism
In a patient with primary hypothyroidism, combined GHRH and GHRP‑6 produced greater delta GH after thyroid replacement than before therapy.
In plain wordsIn a patient with hypothyroidism, the combined peptides produced a greater peak growth hormone rise after thyroid treatment than before treatment.
Peptide
GHRP-6
Outcome
IncreaseCombined peptide delta GH after thyroid replacement
Study
n = 1
Comparator
before thyroid hormone replacement
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Delta GH after GHRH plus GHRP-6
22.7 micrograms/l
before pituitary pseudotumor resolution
Delta GH after GHRH plus GHRP-6
35.5 micrograms/l
after pituitary pseudotumor resolution
Source sentences
Summary
This was accompanied by increased delta GH (22.7 vs 35.5 micrograms/l).
2 context sentences(design, population, supporting numbers)
Summary · context
When the peptides were administered together a synergistic effect on GH secretion was observed but GH release was much more powerful after pituitary pseudotumor disappearance (AUCzero-120 min 1043.2 vs 2046.7 micrograms/l min).
Summary · context
GH secretion after growth hormone-releasing hormone (GHRH), growth hormone releasing peptide-6 (GHRP-6) and after combined administration of both peptides was studied in a patient with lactotrope and thyrotrope hyperplasia due to primary hypothyroidism.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0896113304
05HumanNot a test of GHRP-6 aloneCase report or seriesMechanism
In a patient with primary hypothyroidism, combined GHRH and GHRP‑6 had a synergistic effect on GH secretion.
In plain wordsIn a patient with hypothyroidism, combined GHRH and GHRP‑6 had a synergistic effect on growth hormone release.
Peptide
GHRP-6
Outcome
IncreaseCombined peptide synergistic GH secretion
Study
n = 1
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
When the peptides were administered together a synergistic effect on GH secretion was observed
1 context sentence(design, population, supporting numbers)
Summary · context
GH secretion after growth hormone-releasing hormone (GHRH), growth hormone releasing peptide-6 (GHRP-6) and after combined administration of both peptides was studied in a patient with lactotrope and thyrotrope hyperplasia due to primary hypothyroidism.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0896113305

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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