Influence of the L-arginine-nitric oxide pathway on vasoactive intestinal polypeptide release and motility in the rat stomach in vitro.

Willis S, Allescher HD, Weigert N, Schusdziarra V, Schumpelick V

European journal of pharmacology1 Nov 1996Cited by 11 (Europe PMC)

PMID8960865DOI10.1016/s0014-2999(96)00594-8PepBankPUB-08960865

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelEx vivo tissueMechanism
In the isolated perfused rat stomach, sodium nitroprusside did not significantly change VIP release.
In plain wordsIn lab tests on rat stomach, a nitric oxide donor did not change the stomach's own VIP release.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP release with sodium nitroprusside
Study
ratn = 8
Isolated perfused rat stomach
Outcome group
Neurotransmitters and neurotrophic factors · Gastrointestinal
Source sentences
Summary
P < 0.001) while VIP release was not influenced significantly.
3 context sentences(design, population, supporting numbers)
Summary · context
Arterial perfusion with the nitrate agonist sodiumnitroprusside led to a dose-dependent reduction of the pyloric motility index (basal 166 +/- 48 mm Hg/min: sodiumnitroprusside 10(-6) M 30 +/- 20 mmHg/min: sodiumnitroprusside 10(-4) M 0: n = 8.
Summary · context
The aim of this study was to investigate the influence of NO on pyloric motility and on the release of vasoactive intestinal polypeptide (VIP) in the isolated perfused rat stomach in vitro.
Summary · context
Therefore, pyloric motility was continuously recorded by a special sleeve manometry catheter placed in the pyloric region and the concentration of VIP was determined in the venous effluent of the portal vein.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0896086501
02LabEndogenous levelEx vivo tissueMechanism
In the isolated perfused rat stomach, the NO-synthase inhibitor L-NNA did not influence VIP release.
In plain wordsIn lab tests on rat stomach, blocking nitric oxide production did not change the stomach's own VIP release.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP release with L-NNA
Study
ratn = 8
Isolated perfused rat stomach
Outcome group
Neurotransmitters and neurotrophic factors · Gastrointestinal
Source sentences
Summary
L-NNA and L-Arg both did not influence VIP release.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to investigate the influence of NO on pyloric motility and on the release of vasoactive intestinal polypeptide (VIP) in the isolated perfused rat stomach in vitro.
Summary · context
Therefore, pyloric motility was continuously recorded by a special sleeve manometry catheter placed in the pyloric region and the concentration of VIP was determined in the venous effluent of the portal vein.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0896086502
03LabEndogenous levelEx vivo tissueMechanism
In the isolated perfused rat stomach, L-Arg did not influence VIP release.
In plain wordsIn lab tests on rat stomach, adding L-arginine did not change the stomach's own VIP release.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP release with L-Arg
Study
ratn = 8
Isolated perfused rat stomach
Outcome group
Neurotransmitters and neurotrophic factors · Gastrointestinal
Source sentences
Summary
L-NNA and L-Arg both did not influence VIP release.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to investigate the influence of NO on pyloric motility and on the release of vasoactive intestinal polypeptide (VIP) in the isolated perfused rat stomach in vitro.
Summary · context
Therefore, pyloric motility was continuously recorded by a special sleeve manometry catheter placed in the pyloric region and the concentration of VIP was determined in the venous effluent of the portal vein.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0896086503
04LabEndogenous levelEx vivo tissueMechanism
In the isolated perfused rat stomach, vagal stimulation significantly increased VIP release.
In plain wordsIn lab tests on rat stomach, stimulating the vagal nerve raised the stomach's own VIP release.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP release with vagal stimulation
Study
ratn = 7
Isolated perfused rat stomach
Outcome group
Neurotransmitters and neurotrophic factors · Gastrointestinal
Measurements
VIP release
14.9 pmol/l
basal
VIP release
20.1 pmol/l
vagal stimulation
Source sentences
Summary
Vagal stimulation increased VIP release significantly (basal 14.9 +/- 1.4 pmol/l; VS 20.1 +/- 2.6 pmol/l; n = 7, P < 0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to investigate the influence of NO on pyloric motility and on the release of vasoactive intestinal polypeptide (VIP) in the isolated perfused rat stomach in vitro.
Summary · context
Therefore, pyloric motility was continuously recorded by a special sleeve manometry catheter placed in the pyloric region and the concentration of VIP was determined in the venous effluent of the portal vein.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0896086504
05LabEndogenous levelEx vivo tissueMechanism
In the isolated perfused rat stomach, L-NNA had no influence on vagally induced VIP release.
In plain wordsIn lab tests on rat stomach, blocking nitric oxide production did not change the body's own VIP release caused by vagal nerve stimulation.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP release with vagal stimulation after L-NNA
Study
ratn = 7
Isolated perfused rat stomach
Outcome group
Neurotransmitters and neurotrophic factors · Gastrointestinal
Source sentences
Summary
while L-NNA had no influence on vagally induced VIP release.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to investigate the influence of NO on pyloric motility and on the release of vasoactive intestinal polypeptide (VIP) in the isolated perfused rat stomach in vitro.
Summary · context
Therefore, pyloric motility was continuously recorded by a special sleeve manometry catheter placed in the pyloric region and the concentration of VIP was determined in the venous effluent of the portal vein.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0896086505

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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