Growth hormone response to GHRH, GHRP-6 and GHRH + GHRP-6 in patients with polycystic ovary syndrome.

Micić D, Kendereski A, Popović V, Sumarac M, Zorić S, Macut D, Dieguez C, Casanueva F

Clinical endocrinology1 Oct 1996Cited by 9 (Europe PMC)

PMID8959075DOI10.1046/j.1365-2265.1996.8380848.xPepBankPUB-08959075

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. 2 results from people.

01HumanObservational studyEfficacy outcome
In women with PCOS, GH peak after GHRP‑6 did not differ between non-obese and obese groups.
In plain wordsIn women with PCOS, growth hormone peaks after GHRP‑6 were not different between non-obese and obese women.
Peptide
GHRP-6
Outcome
No significant changeGH peak after GHRP-6, non-obese vs obese PCOS
Study
n = 16
Comparator
Obese PCOS (Group B) vs non-obese PCOS (Group A)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
90 micrograms · intravenousAs given in this study (human).
Source sentences
Summary
while there were no differences between the same groups in GH peak or AUC after GHRP-6 administration.
2 context sentences(design, population, supporting numbers)
Summary · context
All subjects were studied three times on different days with GHRH (100 micrograms i.v.), GHRP-6 (90 micrograms i.v.) and GHRH + GHRP-6 (100 micrograms + 90 micrograms).
Summary · context
Sixteen women with PCOS and 22 healthy controls were studied.
Report a problemFND-0895907501
02HumanObservational studyEfficacy outcome
In women with PCOS, GH AUC after GHRP‑6 did not differ between non-obese and obese groups.
In plain wordsIn women with PCOS, total growth hormone release after GHRP‑6 was not different between non-obese and obese women.
Peptide
GHRP-6
Outcome
No significant changeGH AUC after GHRP-6, non-obese vs obese PCOS
Study
n = 16
Comparator
Obese PCOS (Group B) vs non-obese PCOS (Group A)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
90 micrograms · intravenousAs given in this study (human).
Source sentences
Summary
while there were no differences between the same groups in GH peak or AUC after GHRP-6 administration.
2 context sentences(design, population, supporting numbers)
Summary · context
All subjects were studied three times on different days with GHRH (100 micrograms i.v.), GHRP-6 (90 micrograms i.v.) and GHRH + GHRP-6 (100 micrograms + 90 micrograms).
Summary · context
Sixteen women with PCOS and 22 healthy controls were studied.
Report a problemFND-0895907502

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

03HumanNot a test of GHRP-6 aloneObservational studyEfficacy outcome
In women with PCOS, GH peak after GHRH plus GHRP‑6 was lower in the obese group than in the non-obese group.
In plain wordsIn women with PCOS, GHRH plus GHRP‑6 raised growth hormone less in obese women than in non-obese women.
Peptide
GHRP-6
Outcome
DecreaseGH peak after GHRH plus GHRP-6, non-obese vs obese PCOS
Study
n = 16
Comparator
Obese PCOS (Group B) vs non-obese PCOS (Group A)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH peak
211 mU/l
non-obese PCOS
GH peak
108 mU/l
obese PCOS
Source sentences
Summary
There were significant differences in GH peaks after combined administration of GHRH + GHRP-6 between Groups A and B (211 +/- 26.4 vs 108 +/- 17.6, P < 0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
All subjects were studied three times on different days with GHRH (100 micrograms i.v.), GHRP-6 (90 micrograms i.v.) and GHRH + GHRP-6 (100 micrograms + 90 micrograms).
Summary · context
Sixteen women with PCOS and 22 healthy controls were studied.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0895907503
04HumanNot a test of GHRP-6 aloneObservational studyEfficacy outcome
In women with PCOS, GH AUC after GHRH plus GHRP‑6 was lower in the obese group than in the non-obese group.
In plain wordsIn women with PCOS, total growth hormone release after GHRH plus GHRP‑6 was lower in obese women than in non-obese women.
Peptide
GHRP-6
Outcome
DecreaseGH AUC after GHRH plus GHRP-6, non-obese vs obese PCOS
Study
n = 16
Comparator
Obese PCOS (Group B) vs non-obese PCOS (Group A)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
12,068
non-obese PCOS
GH AUC
5997
obese PCOS
Source sentences
Summary
as well as between GH AUC in Groups A and B (12068 +/- 2323 vs 5997 +/- 1342, P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
All subjects were studied three times on different days with GHRH (100 micrograms i.v.), GHRP-6 (90 micrograms i.v.) and GHRH + GHRP-6 (100 micrograms + 90 micrograms).
Summary · context
Sixteen women with PCOS and 22 healthy controls were studied.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0895907504
05HumanNot a test of GHRP-6 aloneObservational studyEfficacy outcome
In women with PCOS, GH peaks after GHRH plus GHRP‑6 did not differ from matched healthy controls, in non-obese or obese groups.
In plain wordsIn women with PCOS, GHRH plus GHRP‑6 raised growth hormone peaks as much as in matched healthy women.
Peptide
GHRP-6
Outcome
No significant changeGH peak after GHRH plus GHRP-6, PCOS vs controls
Study
n: not reported in source
Comparator
Matched healthy controls
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
There were no differences in GH peaks or AUC for GH after GHRH + GHRP-6 administration between Groups A and C or Groups B and D.
2 context sentences(design, population, supporting numbers)
Summary · context
All subjects were studied three times on different days with GHRH (100 micrograms i.v.), GHRP-6 (90 micrograms i.v.) and GHRH + GHRP-6 (100 micrograms + 90 micrograms).
Summary · context
Sixteen women with PCOS and 22 healthy controls were studied.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0895907505
06HumanNot a test of GHRP-6 aloneObservational studyEfficacy outcome
In women with PCOS, GH AUC after GHRH plus GHRP‑6 did not differ from matched healthy controls, in non-obese or obese groups.
In plain wordsIn women with PCOS, total growth hormone release after GHRH plus GHRP‑6 was similar to that of matched healthy women.
Peptide
GHRP-6
Outcome
No significant changeGH AUC after GHRH plus GHRP-6, PCOS vs controls
Study
n: not reported in source
Comparator
Matched healthy controls
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
There were no differences in GH peaks or AUC for GH after GHRH + GHRP-6 administration between Groups A and C or Groups B and D.
2 context sentences(design, population, supporting numbers)
Summary · context
All subjects were studied three times on different days with GHRH (100 micrograms i.v.), GHRP-6 (90 micrograms i.v.) and GHRH + GHRP-6 (100 micrograms + 90 micrograms).
Summary · context
Sixteen women with PCOS and 22 healthy controls were studied.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0895907506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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