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Study · Animal study (in vivo) · rat · 1996

3 results

Retrogradely labelled neurosecretory neurones of the rat hypothalamic arcuate nucleus express Fos protein following systemic injection of GH-releasing peptide-6.

Dickson SL, Doutrelant-Viltart O, Dyball RE, Leng G

The Journal of endocrinology1 Nov 1996Cited by 21 (Europe PMC)

PMID8958794 (opens in a new tab)DOI10.1677/joe.0.1510323 (opens in a new tab)PepBankPUB-08958794
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, 68% to 82% of arcuate neurones expressing Fos after GHRP‑6 were retrogradely labelled with Fluorogold.

    In plain wordsIn rats, 68% to 82% of arcuate neurons expressing Fos after GHRP‑6 carried the neurosecretory tracer.

    Peptide
    GHRP-6
    Outcome
    Not applicableFluorogold labelling of Fos-positive neurones
    Study

    ratn: not reported in source

    conscious male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    50 micrograms · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Between 68% and 82% of the arcuate neurones expressing Fos protein following GHRP-6 injection were retrogradely labelled with Fluorogold.
    2 context sentences
    Summary · context
    In the first study, adult male rats were injected i.v. with the retrograde tracer, Fluorogold, to detect cells which project outside the blood-brain barrier (and are therefore likely to be neurosecretory neurones).
    Summary · context
    Three days later the conscious rats were injected i.v. with 50 micrograms GHRP-6 and the brains processed for the immunocytochemical detection of Fos protein.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, less than 7% of arcuate neurones expressing Fos after GHRP‑6 contained TH.

    In plain wordsIn rats, less than 7% of arcuate neurons expressing Fos after GHRP‑6 contained TH.

    Peptide
    GHRP-6
    Outcome
    Not applicableTH-containing Fos-positive neurones
    Study

    ratn: not reported in source

    conscious male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    50 micrograms · intravenous · 90 min after injectionAs given in this study (rat).

    Source sentences

    Summary
    Less than 7% (mean +/- S.E.M. = 6.7 +/- 2.6% nuclei/section per rat) of the arcuate neurones expressing Fos protein following GHRP-6 injection were TH-containing cells.
    1 context sentence
    Summary · context
    In the second study, conscious male rats, bearing a chronically implanted jugular catheter, were killed 90 min following an i.v. injection of 50 micrograms GHRP-6 and the brains were processed for the double immunocytochemical detection of Fos protein and either TH or beta-endorphin.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats after GHRP‑6, only four of 143 beta-endorphin-containing arcuate cells contained Fos.

    In plain wordsIn rats after GHRP‑6, only four of 143 beta-endorphin-containing arcuate cells contained Fos.

    Peptide
    GHRP-6
    Outcome
    Not applicableFos in beta-endorphin-containing cells
    Study

    ratn: not reported in source

    conscious male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    50 micrograms · intravenous · 90 min after injectionAs given in this study (rat).

    Source sentences

    Summary
    Of 143 beta-endorphin-containing arcuate cells detected only four cells were identified as containing Fos protein.
    1 context sentence
    Summary · context
    In the second study, conscious male rats, bearing a chronically implanted jugular catheter, were killed 90 min following an i.v. injection of 50 micrograms GHRP-6 and the brains were processed for the double immunocytochemical detection of Fos protein and either TH or beta-endorphin.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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