In rabbit ear wounds, des(1‑3)IGF-I with IGFBP-1 did not improve reepithelialization over controls.
In plain wordsIn rabbits, des(1‑3)IGF-I with IGFBP-1 did not improve wound surface repair compared with controls.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- No significant changeReepithelialization
- Study
rabbitn: not reported in source
Rabbit ear full-thickness dermal wounds- Comparator
- Controls
- Outcome group
- Wound healing · Skin and wound
Source sentences
The same doses of IGF-I/WGD-IGFBP-1, des(1-3)IGF-I/IGFBP-1, and IGF-I/IGFBP-2 were ineffective.
3 context sentences(design, population, supporting numbers)
Only native IGF-I in combination with native IGFBP-1 was effective as a wound healing agent, enhancing reepithelialization and granulation tissue deposition by 64+/-5 and 83+/-12% over controls (P = 0.008 and 0.016, respectively).
Full-thickness dermal wounds were created on rabbit ears; various combinations of native IGF-I, native IGFBP-1, native IGFBP-2, and their respective analogues/mutants were applied to each wound.
Wounds were harvested 7 d later for analysis.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).