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Study · In vitro (cells) · 1996

2 results

Combination of insulin-like growth factor (IGF)-I and IGF-binding protein-1 promotes fibroblast-embedded collagen gel contraction.

Lee YR, Oshita Y, Tsuboi R, Ogawa H

Endocrinology1 Dec 1996Cited by 36 (Europe PMC)

PMID8940346 (opens in a new tab)DOI10.1210/endo.137.12.8940346 (opens in a new tab)PepBankPUB-08940346
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In fibroblast collagen gels, des(1‑3)IGF-I produced significant gel contraction.

    In plain wordsIn cells, des(1‑3)IGF-I increased collagen gel contraction.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseCollagen gel contraction
    Study

    humann: not reported in source

    Human dermal fibroblasts in collagen gels
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    10 ng/mlAs given in this study (human).

    Measurements

    Gel contraction
    4.5%
    des(1-3)IGF-I 10 ng/ml

    Source sentences

    Summary
    and des (1-3) IGF-I at 10 ng/ml produced a 4.5% gel contraction (P < 0.01).
    1 context sentence
    Summary · context
    Human dermal fibroblasts (1 x 10(5) cells/ml) were incorporated into a porcine type I collagen (0.21% final) in serum-free medium.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 02LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Efficacy outcome

    In fibroblast collagen gels, the combination of des(1‑3)IGF-I and IGFBP-1 did not promote gel contraction.

    In plain wordsIn cells, des(1‑3)IGF-I with IGFBP-1 did not increase collagen gel contraction.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeCollagen gel contraction with IGFBP-1
    Study

    humann: not reported in source

    Human dermal fibroblasts in collagen gels
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    whereas combinations of des (1-3) IGF-I with IGFBP-1 at the same concentrations did not promote gel contraction.
    1 context sentence
    Summary · context
    Human dermal fibroblasts (1 x 10(5) cells/ml) were incorporated into a porcine type I collagen (0.21% final) in serum-free medium.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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