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Study · In vitro (cells) · 1996

3 results

Thymosin alpha 1 does not promote growth or oncogenic transformation.

Naylor PH, Smith MR, Mutchnick MG, Naylor CW, Dosescu J, Skunca M, Moshier JA

International journal of immunopharmacology1 May 1996Cited by 2 (Europe PMC)

PMID8933211 (opens in a new tab)DOI10.1016/0192-0561(96)00032-x (opens in a new tab)PepBankPUB-08933211
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured cells, exogenously added thymosin alpha‑1 had no effect on cell growth.

    In plain wordsIn lab tests on cells, thymosin alpha‑1 added to the culture did not change cell growth.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeCell growth with exogenous thymosin alpha 1
    Study

    n: not reported in source

    tumor cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No effect of exogenous T alpha 1 on cell growth was found.
    1 context sentence
    Summary · context
    The studies presented in this report evaluated both exogenously added T alpha 1 and endogenously expressed T alpha 1 as factors which could either promote growth of tumor cells or induce transformation.

Studies that did not test the peptide alone2

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Efficacy outcome

    In NIH-3T3 cells transfected with ProThymosin alpha cDNA that expressed elevated thymosin alpha‑1, proliferation in liquid culture was not enhanced.

    In plain wordsIn cells that made extra thymosin alpha‑1 themselves, lab tests showed no faster growth.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeProliferation of cells expressing thymosin alpha 1
    Study

    n: not reported in source

    NIH-3T3 cells transfected with ProThymosin alpha cDNA
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    NIH-3T3 cells transfected with cDNA for the precursor ProThymosin alpha (Pro T alpha) expressed elevated levels of authentic T alpha 1 but did not demonstrate either enhanced proliferation in liquid culture or transformation as defined by the loss of contact inhibition or anchorage independent growth in soft agar.
    1 context sentence
    Summary · context
    The studies presented in this report evaluated both exogenously added T alpha 1 and endogenously expressed T alpha 1 as factors which could either promote growth of tumor cells or induce transformation.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Efficacy outcome

    In NIH-3T3 cells transfected with ProThymosin alpha cDNA that expressed elevated thymosin alpha‑1, there was no transformation, with no loss of contact inhibition and no anchorage-independent growth in soft agar.

    In plain wordsIn cells that made extra thymosin alpha‑1 themselves, lab tests showed no signs of cancer-like transformation.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeOncogenic transformation of cells expressing thymosin alpha 1
    Study

    n: not reported in source

    NIH-3T3 cells transfected with ProThymosin alpha cDNA
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    NIH-3T3 cells transfected with cDNA for the precursor ProThymosin alpha (Pro T alpha) expressed elevated levels of authentic T alpha 1 but did not demonstrate either enhanced proliferation in liquid culture or transformation as defined by the loss of contact inhibition or anchorage independent growth in soft agar.
    1 context sentence
    Summary · context
    The studies presented in this report evaluated both exogenously added T alpha 1 and endogenously expressed T alpha 1 as factors which could either promote growth of tumor cells or induce transformation.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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