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Study · Animal study (in vivo) · rat · 1996

4 results

Modulation of dopaminergic neurotransmission in the 6-hydroxydopamine lesioned rotational model by peptidomimetic analogues of L-prolyl-L-leucyl-glycinamide.

Ott MC, Mishra RK, Johnson RL

Brain research1 Oct 1996Cited by 15 (Europe PMC)

PMID8930377 (opens in a new tab)DOI10.1016/0006-8993(96)00927-4 (opens in a new tab)PepBankPUB-08930377
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In lesioned Wistar rats, PLG showed a bell-shaped dose-response for apomorphine-induced rotational behavior.

    In plain wordsIn rats with brain lesions, PLG showed a bell-shaped response in rotations caused by apomorphine.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    MixedRotational dose-response
    Study

    ratn: not reported in source

    6-hydroxydopamine unilateral lesion model in Wistar rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PLG and the two novel analogues showed a bell-shaped dose-response relationship, suggesting that analogue A, B and PLG all manifest their effect through a similar mechanism and exhibit a window of therapeutic efficacy.
    1 context sentence
    Summary · context
    In the present study the 6-hydroxydopamine unilateral lesion model of apomorphine-induced rotational behaviour, in Wistar rats,
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In lesioned rats, PLG was less potent than analogue A in increasing apomorphine-induced contralateral rotations.

    In plain wordsIn rats with lesions, PLG increased apomorphine-induced rotations less potently than analogue A.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseRotational response potency versus analogue A
    Study

    ratn: not reported in source

    6-hydroxydopamine unilateral lesion model in Wistar rats
    Comparator
    Analogue A
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Analogue A potency relative to PLG
    100 fold
    Increasing contralateral rotations with apomorphine

    Source sentences

    Summary
    Analogue A was a 100 times, while analogue B was 10 times, more potent than PLG in increasing the contralateral rotational response when given in combination with apomorphine.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In lesioned rats, PLG was less potent than analogue B in increasing apomorphine-induced contralateral rotations.

    In plain wordsIn rats with lesions, PLG increased apomorphine-induced rotations less potently than analogue B.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseRotational response potency versus analogue B
    Study

    ratn: not reported in source

    6-hydroxydopamine unilateral lesion model in Wistar rats
    Comparator
    Analogue B
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Analogue B potency relative to PLG
    10 fold
    Increasing contralateral rotations with apomorphine

    Source sentences

    Summary
    Analogue A was a 100 times, while analogue B was 10 times, more potent than PLG in increasing the contralateral rotational response when given in combination with apomorphine.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In lesioned rats, PLG was less efficacious than analogue A at increasing apomorphine-induced contralateral rotations.

    In plain wordsIn rats with lesions, PLG increased apomorphine-induced rotations less effectively than analogue A.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseRotational response efficacy versus analogue A
    Study

    ratn: not reported in source

    6-hydroxydopamine unilateral lesion model in Wistar rats
    Comparator
    Analogue A
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Analogue A was also more efficacious than PLG or analogue B at increasing apomorphine-induced contralateral rotations.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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