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Study · Ex vivo tissue · rat · 1996

5 results

Brain-derived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices.

Xiong H, Baskys A, Wojtowicz JM

Brain research1 Oct 1996Cited by 23 (Europe PMC)

PMID8930365 (opens in a new tab)DOI10.1016/0006-8993(96)00731-7 (opens in a new tab)PepBankPUB-08930365
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat hippocampal slices, Cerebrolysin acted preferentially on presynaptic GABAB receptors, unlike baclofen or GABA.

    In plain wordsIn lab tests with rat brain slices, Cerebrolysin preferred presynaptic GABAB receptors, unlike baclofen or GABA.

    Peptide
    Cerebrolysin
    Outcome
    Not applicablePresynaptic receptor preference
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 area
    Comparator
    Baclofen or GABA
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to other, presently known agonists, such as baclofen or GABA, Cerebrolysin acts preferentially on presynaptic GABAB receptors and has no detectable postsynaptic inhibitory effects.
    2 context sentences
    Title · context
    Brain-derived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices.
    Summary · context
    The agent is a component of a nootropic drug, Cerebrolysin, obtained from pig's brain extract.
  2. 02LabEx vivo tissueMechanism

    In rat hippocampal slices, Cerebrolysin had no detectable postsynaptic inhibitory effects, unlike baclofen or GABA.

    In plain wordsIn lab tests with rat brain slices, Cerebrolysin had no detectable postsynaptic inhibitory effects, unlike baclofen or GABA.

    Peptide
    Cerebrolysin
    Outcome
    No significant changePostsynaptic inhibition
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 area
    Comparator
    Baclofen or GABA
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to other, presently known agonists, such as baclofen or GABA, Cerebrolysin acts preferentially on presynaptic GABAB receptors and has no detectable postsynaptic inhibitory effects.
    2 context sentences
    Title · context
    Brain-derived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices.
    Summary · context
    The agent is a component of a nootropic drug, Cerebrolysin, obtained from pig's brain extract.
  3. 03LabEx vivo tissueMechanism

    In rat hippocampal slices, Cerebrolysin produced additional postsynaptic depolarization distinct from its GABAB response.

    In plain wordsIn lab tests with rat brain slices, Cerebrolysin also produced postsynaptic depolarization.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePostsynaptic depolarization
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 area
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additional, postsynaptic depolarizing action of the drug resulting in increased excitability is pharmacologically distinct from the GABAB response and partially masked by the inhibition.
    2 context sentences
    Title · context
    Brain-derived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices.
    Summary · context
    The agent is a component of a nootropic drug, Cerebrolysin, obtained from pig's brain extract.
  4. 04LabEx vivo tissueMechanism

    In rat hippocampal slices, Cerebrolysin's postsynaptic depolarizing action increased excitability and was partially masked by inhibition.

    In plain wordsIn lab tests with rat brain slices, Cerebrolysin's depolarizing action increased excitability and was partly masked by inhibition.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseExcitability
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 area
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additional, postsynaptic depolarizing action of the drug resulting in increased excitability is pharmacologically distinct from the GABAB response and partially masked by the inhibition.
    2 context sentences
    Title · context
    Brain-derived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices.
    Summary · context
    The agent is a component of a nootropic drug, Cerebrolysin, obtained from pig's brain extract.

Studies that did not test the peptide alone1

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 05LabNot a test of Cerebrolysin aloneEx vivo tissueMechanism

    In rat hippocampal slices, a Cerebrolysin component inhibited CA1 synaptic transmission through GABAB receptors.

    In plain wordsIn lab tests with rat brain slices, a Cerebrolysin component inhibited synaptic transmission through GABAB receptors.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSynaptic transmission
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 area
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    We report here on a novel pharmacological agent, presumably a peptide, which inhibits synaptic transmission in the CA1 area of the rat hippocampus via GABAB receptors.
    2 context sentences
    Summary · context
    The agent is a component of a nootropic drug, Cerebrolysin, obtained from pig's brain extract.
    Title · context
    Brain-derived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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