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Study · Measured the body's own peptide · 1996

2 results

Effect of central administration of the kappa-opiate receptor agonist U 69.593 on neurohypophyseal hormone levels in blood and cerebrospinal fluid.

van Wimersma Greidanus TB, Janssen S, Frankhuijzen-Sierevogel JC, Maigret C, van de Heijning BJ

Neuropeptides1 Oct 1996Cited by 6 (Europe PMC)

PMID8923507 (opens in a new tab)DOI10.1016/s0143-4179(96)90009-8 (opens in a new tab)PepBankPUB-08923507
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In water-deprived rats, intracerebroventricular U 69.593 induced a rapid, short lasting suppression of plasma oxytocin levels.

    In plain wordsIn water-deprived rats, a kappa-opioid drug quickly and briefly lowered the body's own oxytocin in blood.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma oxytocin level after U 69.593
    Study

    ratn: not reported in source

    water-deprived rats, i.c.v. U 69.593
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Intracerebroventricular (i.c.v.) administration of the kappa-opiate receptor agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) levels in plasma of water deprived rats
    1 context sentence
    Summary · context
    Intracerebroventricular (i.c.v.) administration of the kappa-opiate receptor agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) levels in plasma of water deprived rats, whereas only a tendency towards a suppression of vasopressin (AVP) levels in plasma is observed.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, intracerebroventricular U 69.593 did not change neurohypophyseal hormone levels in cerebrospinal fluid at the time points studied.

    In plain wordsIn rats, a kappa-opioid drug did not change the body's own oxytocin and vasopressin levels in spinal fluid.

    Peptide
    Oxytocin
    Outcome
    No significant changeCSF oxytocin level after U 69.593
    Study

    ratn: not reported in source

    water-deprived rats, i.c.v. U 69.593
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    No change in neurohypophyseal hormone levels in CSF occurs following i.c.v. administration of U 69.593 at the various times points studied.
    1 context sentence
    Summary · context
    Intracerebroventricular (i.c.v.) administration of the kappa-opiate receptor agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) levels in plasma of water deprived rats, whereas only a tendency towards a suppression of vasopressin (AVP) levels in plasma is observed.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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