Is continuous intranasal salmon calcitonin effective in treating axial bone loss in patients with active rheumatoid arthritis receiving low dose glucocorticoid therapy?

Kotaniemi A, Piirainen H, Paimela L, Leirisalo-Repo M, Uoti-Reilama K, Lahdentausta P, Ruotsalainen P, Kataja M, Väisänen E, Kurki P

The Journal of rheumatology1 Nov 1996Cited by 30 (Europe PMC)

PMID8923359PepBankPUB-08923359

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanNon-randomized trialEfficacy outcome
In women with rheumatoid arthritis, salmon calcitonin improved femoral neck BMD change versus calcium alone.
In plain wordsIn women with rheumatoid arthritis, salmon calcitonin improved femoral neck bone density change versus calcium alone.
Peptide
Calcitonin-salmon
Outcome
IncreaseFemoral neck BMD change
Study
n = 49
Comparator
Calcium alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day · intranasal · 12 monthsAs given in this study (human).
Source sentences
Summary
The differences of the changes in BMD were statistically significant between these groups at the femoral neck, Ward's triangle, and trochanter.
3 context sentences(design, population, supporting numbers)
Summary · context
Among valid completers treated with sCT and Ca (n = 26), the mean BMD increased at the lumbar spine (L1-L4), femoral neck, and Ward's triangle.
Summary · context
In contrast, valid completers treated with Ca (n = 23) showed bone loss at the spine (L1-L4), femoral neck, Ward's triangle, and trochanter area.
Summary · context
In this open, multicenter study 32 women with RA were treated one year with sCT 100 IU/day and calcium (Ca) 500 mg/day; 31 women were treated with Ca alone.
Report a problemFND-0892335904
02HumanNon-randomized trialEfficacy outcome
In women with rheumatoid arthritis, salmon calcitonin improved Ward's triangle BMD change versus calcium alone.
In plain wordsIn women with rheumatoid arthritis, salmon calcitonin improved Ward's triangle bone density change versus calcium alone.
Peptide
Calcitonin-salmon
Outcome
IncreaseWard's triangle BMD change
Study
n = 49
Comparator
Calcium alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day · intranasal · 12 monthsAs given in this study (human).
Source sentences
Summary
The differences of the changes in BMD were statistically significant between these groups at the femoral neck, Ward's triangle, and trochanter.
3 context sentences(design, population, supporting numbers)
Summary · context
Among valid completers treated with sCT and Ca (n = 26), the mean BMD increased at the lumbar spine (L1-L4), femoral neck, and Ward's triangle.
Summary · context
In contrast, valid completers treated with Ca (n = 23) showed bone loss at the spine (L1-L4), femoral neck, Ward's triangle, and trochanter area.
Summary · context
In this open, multicenter study 32 women with RA were treated one year with sCT 100 IU/day and calcium (Ca) 500 mg/day; 31 women were treated with Ca alone.
Report a problemFND-0892335905
03HumanNon-randomized trialEfficacy outcome
In women with rheumatoid arthritis, the change in trochanter BMD differed significantly between salmon calcitonin with calcium and calcium alone, which showed bone loss there.
In plain wordsIn women with rheumatoid arthritis, trochanter bone density change differed significantly between salmon calcitonin and calcium alone, which lost bone there.
Peptide
Calcitonin-salmon
Outcome
Direction not reportedTrochanter BMD change
Study
n = 49
Comparator
Calcium alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day · intranasal · 12 monthsAs given in this study (human).
Source sentences
Summary
The differences of the changes in BMD were statistically significant between these groups at the femoral neck, Ward's triangle, and trochanter.
2 context sentences(design, population, supporting numbers)
Summary · context
In contrast, valid completers treated with Ca (n = 23) showed bone loss at the spine (L1-L4), femoral neck, Ward's triangle, and trochanter area.
Summary · context
In this open, multicenter study 32 women with RA were treated one year with sCT 100 IU/day and calcium (Ca) 500 mg/day; 31 women were treated with Ca alone.
Report a problemFND-0892335906
04HumanNon-randomized trialEfficacy outcome
In women with rheumatoid arthritis, lumbar spine bone loss did not differ significantly between salmon calcitonin and calcium alone.
In plain wordsIn women with rheumatoid arthritis, spine bone loss did not differ significantly between salmon calcitonin and calcium alone.
Peptide
Calcitonin-salmon
Outcome
No significant changeLumbar spine bone loss
Study
n = 49
Comparator
Calcium alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day · intranasal · 12 monthsAs given in this study (human).
Source sentences
Summary
There were no significant differences between groups in bone loss over 12 months at the lumbar spine (L1-L4), although analysis of the upper segment (L1-L2) suggested some possible benefit of sCT.
1 context sentence(design, population, supporting numbers)
Summary · context
In this open, multicenter study 32 women with RA were treated one year with sCT 100 IU/day and calcium (Ca) 500 mg/day; 31 women were treated with Ca alone.
Report a problemFND-0892335907
05HumanNon-randomized trialEfficacy outcome
In women with rheumatoid arthritis, L1-L2 analysis suggested possible benefit from salmon calcitonin versus calcium alone.
In plain wordsIn women with rheumatoid arthritis, upper spine analysis suggested possible benefit from salmon calcitonin versus calcium alone.
Peptide
Calcitonin-salmon
Outcome
Direction not reportedUpper lumbar spine L1-L2 bone loss
Study
n = 49
Comparator
Calcium alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day · intranasal · 12 monthsAs given in this study (human).
Source sentences
Summary
There were no significant differences between groups in bone loss over 12 months at the lumbar spine (L1-L4), although analysis of the upper segment (L1-L2) suggested some possible benefit of sCT.
3 context sentences(design, population, supporting numbers)
Summary · context
In this open, multicenter study 32 women with RA were treated one year with sCT 100 IU/day and calcium (Ca) 500 mg/day; 31 women were treated with Ca alone.
Summary · context
Among valid completers treated with sCT and Ca (n = 26), the mean BMD increased at the lumbar spine (L1-L4), femoral neck, and Ward's triangle.
Summary · context
In contrast, valid completers treated with Ca (n = 23) showed bone loss at the spine (L1-L4), femoral neck, Ward's triangle, and trochanter area.
Report a problemFND-0892335908
06HumanNon-randomized trialEfficacy outcome
In women with rheumatoid arthritis, salmon calcitonin with calcium increased lumbar spine BMD from baseline.
In plain wordsIn women with rheumatoid arthritis, salmon calcitonin with calcium increased spine bone density from baseline.
Peptide
Calcitonin-salmon
Outcome
IncreaseLumbar spine BMD
Study
n = 26
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day · intranasal · 12 monthsAs given in this study (human).
Source sentences
Summary
Among valid completers treated with sCT and Ca (n = 26), the mean BMD increased at the lumbar spine (L1-L4), femoral neck, and Ward's triangle.
1 context sentence(design, population, supporting numbers)
Summary · context
In this open, multicenter study 32 women with RA were treated one year with sCT 100 IU/day and calcium (Ca) 500 mg/day; 31 women were treated with Ca alone.
Report a problemFND-0892335901
07HumanNon-randomized trialEfficacy outcome
In women with rheumatoid arthritis, salmon calcitonin with calcium increased femoral neck BMD from baseline.
In plain wordsIn women with rheumatoid arthritis, salmon calcitonin with calcium increased femoral neck bone density from baseline.
Peptide
Calcitonin-salmon
Outcome
IncreaseFemoral neck BMD
Study
n = 26
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day · intranasal · 12 monthsAs given in this study (human).
Source sentences
Summary
Among valid completers treated with sCT and Ca (n = 26), the mean BMD increased at the lumbar spine (L1-L4), femoral neck, and Ward's triangle.
1 context sentence(design, population, supporting numbers)
Summary · context
In this open, multicenter study 32 women with RA were treated one year with sCT 100 IU/day and calcium (Ca) 500 mg/day; 31 women were treated with Ca alone.
Report a problemFND-0892335902
08HumanNon-randomized trialEfficacy outcome
In women with rheumatoid arthritis, salmon calcitonin with calcium increased Ward's triangle BMD from baseline.
In plain wordsIn women with rheumatoid arthritis, salmon calcitonin with calcium increased Ward's triangle bone density from baseline.
Peptide
Calcitonin-salmon
Outcome
IncreaseWard's triangle BMD
Study
n = 26
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day · intranasal · 12 monthsAs given in this study (human).
Source sentences
Summary
Among valid completers treated with sCT and Ca (n = 26), the mean BMD increased at the lumbar spine (L1-L4), femoral neck, and Ward's triangle.
1 context sentence(design, population, supporting numbers)
Summary · context
In this open, multicenter study 32 women with RA were treated one year with sCT 100 IU/day and calcium (Ca) 500 mg/day; 31 women were treated with Ca alone.
Report a problemFND-0892335903

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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